Entry | Database: PDB / ID: 6p54 |
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Title | Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae acylated by ceftriaxone |
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Components | Probable peptidoglycan D,D-transpeptidase PenA |
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Keywords | HYDROLASE/ANTIBIOTIC / Penicillin-binding protein / transpeptidase domain / Neisseria gonorrhoeae / antibiotic resistance / HYDROLASE-ANTIBIOTIC complex |
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Function / homology | Function and homology information
peptidoglycan glycosyltransferase activity / serine-type D-Ala-D-Ala carboxypeptidase / FtsZ-dependent cytokinesis / serine-type D-Ala-D-Ala carboxypeptidase activity / division septum assembly / penicillin binding / peptidoglycan biosynthetic process / cell wall organization / regulation of cell shape / response to antibiotic ...peptidoglycan glycosyltransferase activity / serine-type D-Ala-D-Ala carboxypeptidase / FtsZ-dependent cytokinesis / serine-type D-Ala-D-Ala carboxypeptidase activity / division septum assembly / penicillin binding / peptidoglycan biosynthetic process / cell wall organization / regulation of cell shape / response to antibiotic / proteolysis / plasma membraneSimilarity search - Function Peptidoglycan D,D-transpeptidase FtsI / Penicillin-binding protein, dimerisation domain / Penicillin-binding Protein dimerisation domain / Penicillin-binding protein, dimerisation domain superfamily / : / Penicillin-binding protein, transpeptidase / Penicillin binding protein transpeptidase domain / Beta-lactamase / DD-peptidase/beta-lactamase superfamily / Beta-lactamase/transpeptidase-like ...Peptidoglycan D,D-transpeptidase FtsI / Penicillin-binding protein, dimerisation domain / Penicillin-binding Protein dimerisation domain / Penicillin-binding protein, dimerisation domain superfamily / : / Penicillin-binding protein, transpeptidase / Penicillin binding protein transpeptidase domain / Beta-lactamase / DD-peptidase/beta-lactamase superfamily / Beta-lactamase/transpeptidase-like / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology Ceftriaxone / CEFOTAXIME, C3' cleaved, open, bound form / ceftriaxone, bound form / DI(HYDROXYETHYL)ETHER / Probable peptidoglycan D,D-transpeptidase PenASimilarity search - Component |
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Biological species | Neisseria gonorrhoeae (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / FOURIER SYNTHESIS / Resolution: 1.83 Å |
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Authors | Singh, A. / Davies, C. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM066861 | United States |
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Citation | Journal: J.Biol.Chem. / Year: 2019 Title: Recognition of the beta-lactam carboxylate triggers acylation ofNeisseria gonorrhoeaepenicillin-binding protein 2. Authors: Singh, A. / Tomberg, J. / Nicholas, R.A. / Davies, C. |
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History | Deposition | May 29, 2019 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Aug 7, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 14, 2019 | Group: Data collection / Database references / Category: citation / citation_author Item: _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed ..._citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID |
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Revision 1.2 | Oct 2, 2019 | Group: Data collection / Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID |
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Revision 1.3 | Jan 1, 2020 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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