登録情報 データベース : PDB / ID : 6p3v 構造の表示 ダウンロードとリンクタイトル Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT416 要素N-acetyltransferase Eis 詳細 キーワード transferase/transferase inhibitor / Acetyltransferase / Aminoglycoside resistance / Competitive inhibitor / TRANSFERASE / transferase-transferase inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
effector-mediated defense to host-produced reactive oxygen species / symbiont-mediated perturbation of host inflammatory response / symbiont-mediated suppression of host defense-related programmed cell death / aminoglycoside antibiotic catabolic process / aminoglycoside N-acetyltransferase activity / symbiont-mediated perturbation of host innate immune response / Suppression of autophagy / symbiont-mediated perturbation of host programmed cell death / bacterial extracellular vesicle / biological process involved in interaction with host ... effector-mediated defense to host-produced reactive oxygen species / symbiont-mediated perturbation of host inflammatory response / symbiont-mediated suppression of host defense-related programmed cell death / aminoglycoside antibiotic catabolic process / aminoglycoside N-acetyltransferase activity / symbiont-mediated perturbation of host innate immune response / Suppression of autophagy / symbiont-mediated perturbation of host programmed cell death / bacterial extracellular vesicle / biological process involved in interaction with host / host cell cytoplasmic vesicle / N-acetyltransferase activity / peptide-lysine-N-acetyltransferase activity / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / host extracellular space / response to antibiotic / identical protein binding / cytosol 類似検索 - 分子機能 : / N-acetyltransferase Eis / Enhanced intracellular survival protein domain / Eis-like, acetyltransferase domain / Sterol carrier protein domain / Acetyltransferase (GNAT) domain / Acetyltransferase (GNAT) domain / SCP2 sterol-binding domain / Nonspecific Lipid-transfer Protein; Chain A / SCP2 sterol-binding domain superfamily ... : / N-acetyltransferase Eis / Enhanced intracellular survival protein domain / Eis-like, acetyltransferase domain / Sterol carrier protein domain / Acetyltransferase (GNAT) domain / Acetyltransferase (GNAT) domain / SCP2 sterol-binding domain / Nonspecific Lipid-transfer Protein; Chain A / SCP2 sterol-binding domain superfamily / Gcn5-related N-acetyltransferase (GNAT) / Gcn5-related N-acetyltransferase (GNAT) domain profile. / GNAT domain / Acyl-CoA N-acyltransferase / Aminopeptidase / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Mycobacterium tuberculosis (結核菌)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.5 Å 詳細データ登録者 Punetha, A. / Garneau-Tsodikova, S. / Tsodikov, O.V. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) R01AI090048 米国
引用ジャーナル : Acs Infect Dis. / 年 : 2019タイトル : Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis.著者 : Green, K.D. / Punetha, A. / Hou, C. / Garneau-Tsodikova, S. / Tsodikov, O.V. 履歴 登録 2019年5月24日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2019年9月4日 Provider : repository / タイプ : Initial release改定 1.1 2019年10月23日 Group : Data collection / Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.2 2019年12月18日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.3 2023年10月11日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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