- PDB-6p1w: Pre-catalytic ternary complex of human DNA Polymerase Mu with 1-n... -
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基本情報
登録情報
データベース: PDB / ID: 6p1w
タイトル
Pre-catalytic ternary complex of human DNA Polymerase Mu with 1-nt gapped substrate containing undamaged template dG and bound incoming CMPCPP
要素
DNA (5'-D(*CP*GP*GP*CP*GP*TP*AP*CP*G)-3')
DNA (5'-D(*CP*GP*TP*A)-3')
DNA (5'-D(P*GP*CP*CP*G)-3')
DNA-directed DNA/RNA polymerase mu
キーワード
TRANSFERASE / Family X polymerase / NHEJ
機能・相同性
機能・相同性情報
Nonhomologous End-Joining (NHEJ) / double-strand break repair via nonhomologous end joining / DNA recombination / DNA-directed DNA polymerase / DNA-directed DNA polymerase activity / DNA binding / nucleoplasm / nucleus / metal ion binding 類似検索 - 分子機能
DNA-directed DNA/RNA polymerase mu / DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu / Beta Polymerase; domain 3 / DNA polymerase, thumb domain / DNA polymerase beta, N-terminal domain-like / DNA polymerase beta, palm domain / DNA polymerase beta palm / DNA polymerase lambda, fingers domain / Fingers domain of DNA polymerase lambda / DNA-directed DNA polymerase X ...DNA-directed DNA/RNA polymerase mu / DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu / Beta Polymerase; domain 3 / DNA polymerase, thumb domain / DNA polymerase beta, N-terminal domain-like / DNA polymerase beta, palm domain / DNA polymerase beta palm / DNA polymerase lambda, fingers domain / Fingers domain of DNA polymerase lambda / DNA-directed DNA polymerase X / DNA polymerase beta-like, N-terminal domain / Helix-hairpin-helix domain / DNA polymerase X family / DNA polymerase family X, binding site / DNA polymerase family X signature. / DNA polymerase lambda lyase domain superfamily / DNA polymerase family X / DNA polymerase beta, thumb domain / DNA polymerase beta thumb / DNA polymerase, thumb domain superfamily / Beta Polymerase, domain 2 / Beta Polymerase; domain 2 / BRCT domain profile. / BRCT domain / BRCT domain superfamily / Nucleotidyltransferase superfamily / 5' to 3' exonuclease, C-terminal subdomain / DNA polymerase; domain 1 / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性
Chem-2TM / DNA / DNA-directed DNA/RNA polymerase mu 類似検索 - 構成要素
根拠: gel filtration, tetramer consists of one protein molecule (chain A) bound to one DNA duplex comprised of three annealed DNA strands (chains T, P, and D)
タイプ
名称
対称操作
数
identity operation
1_555
x,y,z
1
Buried area
5270 Å2
ΔGint
-83 kcal/mol
Surface area
16110 Å2
手法
PISA
単位格子
Length a, b, c (Å)
59.802, 68.692, 110.065
Angle α, β, γ (deg.)
90.00, 90.00, 90.00
Int Tables number
19
Space group name H-M
P212121
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要素
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タンパク質 , 1種, 1分子 A
#1: タンパク質
DNA-directedDNA/RNApolymerasemu / Pol Mu / Terminal transferase