登録情報 | データベース: PDB / ID: 6oqa |
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タイトル | Crystal structure of CEP250 bound to FKBP12 in the presence of FK506-like novel natural product |
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要素 | - Centrosome-associated protein CEP250
- Peptidyl-prolyl cis-trans isomerase FKBP1A
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キーワード | CELL CYCLE / ISOMERASE / FKBP12 / CEP250 / natural product / ternary complex |
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機能・相同性 | 機能・相同性情報
centriole-centriole cohesion / protein localization to organelle / detection of light stimulus involved in visual perception / regulation of centriole-centriole cohesion / : / macrolide binding / activin receptor binding / cytoplasmic side of membrane / positive regulation of protein localization to centrosome / signaling receptor inhibitor activity ...centriole-centriole cohesion / protein localization to organelle / detection of light stimulus involved in visual perception / regulation of centriole-centriole cohesion / : / macrolide binding / activin receptor binding / cytoplasmic side of membrane / positive regulation of protein localization to centrosome / signaling receptor inhibitor activity / transforming growth factor beta receptor binding / TGFBR1 LBD Mutants in Cancer / type I transforming growth factor beta receptor binding / negative regulation of activin receptor signaling pathway / non-motile cilium assembly / heart trabecula formation / terminal cisterna / ryanodine receptor complex / I-SMAD binding / regulation of amyloid precursor protein catabolic process / protein maturation by protein folding / ventricular cardiac muscle tissue morphogenesis / 'de novo' protein folding / microtubule organizing center / negative regulation of phosphoprotein phosphatase activity / FK506 binding / mTORC1-mediated signalling / TGF-beta receptor signaling activates SMADs / Calcineurin activates NFAT / photoreceptor outer segment / cilium assembly / regulation of immune response / protein peptidyl-prolyl isomerization / heart morphogenesis / supramolecular fiber organization / regulation of ryanodine-sensitive calcium-release channel activity / Loss of Nlp from mitotic centrosomes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of mitotic centrosome proteins and complexes / Recruitment of NuMA to mitotic centrosomes / sarcoplasmic reticulum membrane / Anchoring of the basal body to the plasma membrane / T cell activation / centriole / photoreceptor inner segment / AURKA Activation by TPX2 / ciliary basal body / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / peptidylprolyl isomerase / sarcoplasmic reticulum / peptidyl-prolyl cis-trans isomerase activity / calcium ion transmembrane transport / negative regulation of transforming growth factor beta receptor signaling pathway / protein localization / Z disc / SARS-CoV-1 activates/modulates innate immune responses / regulation of protein localization / Regulation of PLK1 Activity at G2/M Transition / protein folding / positive regulation of protein binding / mitotic cell cycle / protein refolding / positive regulation of canonical NF-kappaB signal transduction / transmembrane transporter binding / amyloid fibril formation / Potential therapeutics for SARS / protein domain specific binding / centrosome / protein kinase binding / perinuclear region of cytoplasm / protein-containing complex / extracellular exosome / membrane / cytoplasm / cytosol類似検索 - 分子機能 Chitinase A; domain 3 - #40 / Chitinase A; domain 3 / FKBP-type peptidyl-prolyl cis-trans isomerase domain profile. / FKBP-type peptidyl-prolyl cis-trans isomerase domain / FKBP-type peptidyl-prolyl cis-trans isomerase / Peptidyl-prolyl cis-trans isomerase domain superfamily / Roll / Alpha Beta類似検索 - ドメイン・相同性 Chem-60Z / MALONIC ACID / 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL / DI(HYDROXYETHYL)ETHER / TRIETHYLENE GLYCOL / Peptidyl-prolyl cis-trans isomerase FKBP1A / Centrosome-associated protein CEP250類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.2 Å |
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データ登録者 | Lee, S.-J. / Shigdel, U.K. / Townson, S.A. / Verdine, G.L. |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2020 タイトル: Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface. 著者: Shigdel, U.K. / Lee, S.J. / Sowa, M.E. / Bowman, B.R. / Robison, K. / Zhou, M. / Pua, K.H. / Stiles, D.T. / Blodgett, J.A.V. / Udwary, D.W. / Rajczewski, A.T. / Mann, A.S. / Mostafavi, S. / ...著者: Shigdel, U.K. / Lee, S.J. / Sowa, M.E. / Bowman, B.R. / Robison, K. / Zhou, M. / Pua, K.H. / Stiles, D.T. / Blodgett, J.A.V. / Udwary, D.W. / Rajczewski, A.T. / Mann, A.S. / Mostafavi, S. / Hardy, T. / Arya, S. / Weng, Z. / Stewart, M. / Kenyon, K. / Morgenstern, J.P. / Pan, E. / Gray, D.C. / Pollock, R.M. / Fry, A.M. / Klausner, R.D. / Townson, S.A. / Verdine, G.L. |
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履歴 | 登録 | 2019年4月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年4月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年11月11日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2024年3月13日 | Group: Advisory / Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_unobs_or_zero_occ_atoms Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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