Entry Database : PDB / ID : 6ogs Structure visualization Downloads & linksTitle X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in complex with GRL-001 ComponentsProtease Details Keywords VIRAL PROTEIN/INHIBITOR / Inhibitor / VIRAL PROTEIN / VIRAL PROTEIN-INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
Retropepsin-like catalytic domain / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily ... Retropepsin-like catalytic domain / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Human immunodeficiency virus 1Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.27 Å DetailsAuthors Bulut, H. / Hattori, S.I. / Aoki-Ogata, H. / Hayashi, H. / Aoki, M. / Ghosh, A.K. / Mitsuya, H. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Cancer Institute (NIH/NCI) United States
CitationJournal : Sci Rep / Year : 2020Title : Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity.Authors : Bulut, H. / Hattori, S.I. / Aoki-Ogata, H. / Hayashi, H. / Das, D. / Aoki, M. / Davis, D.A. / Rao, K.V. / Nyalapatla, P.R. / Ghosh, A.K. / Mitsuya, H. History Deposition Apr 3, 2019 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 8, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Aug 26, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Apr 28, 2021 Group : Data collection / Category : diffrn_sourceItem : _diffrn_source.pdbx_synchrotron_beamline / _diffrn_source.typeRevision 1.3 Oct 11, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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