Entry Database : PDB / ID : 6oa6 Structure visualization Downloads & linksTitle CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OF HUMAN ALPHA-ACTININ-4 ComponentsAlpha-actinin-4 Details Keywords STRUCTURAL PROTEIN / CALPONIN HOMOLOGY DOMAIN / CH DOMAIN / ACTIN- BINDING PROTEIN / ACTIN-CROSSLINKING / GLOMERULOSCLEROS SPECTRIN FAMILY / DISEASE MUTATION / NUCLEUS / PHOSPHORYLATIONFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of sodium:proton antiporter activity / negative regulation of substrate adhesion-dependent cell spreading / postsynaptic actin cytoskeleton / vesicle transport along actin filament / nucleoside binding / muscle cell development / nuclear retinoic acid receptor binding / Nephrin family interactions / cortical actin cytoskeleton / pseudopodium ... positive regulation of sodium:proton antiporter activity / negative regulation of substrate adhesion-dependent cell spreading / postsynaptic actin cytoskeleton / vesicle transport along actin filament / nucleoside binding / muscle cell development / nuclear retinoic acid receptor binding / Nephrin family interactions / cortical actin cytoskeleton / pseudopodium / retinoic acid receptor signaling pathway / stress fiber / tumor necrosis factor-mediated signaling pathway / peroxisome proliferator activated receptor signaling pathway / platelet alpha granule lumen / nuclear receptor coactivator activity / cell projection / nuclear receptor binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / chromatin DNA binding / Z disc / positive regulation of non-canonical NF-kappaB signal transduction / actin filament binding / actin cytoskeleton / integrin binding / protein transport / Platelet degranulation / cell junction / actin binding / actin cytoskeleton organization / regulation of apoptotic process / transmembrane transporter binding / transcription coactivator activity / positive regulation of cell migration / ribonucleoprotein complex / focal adhesion / calcium ion binding / perinuclear region of cytoplasm / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / RNA binding / extracellular space / extracellular exosome / extracellular region / nucleus / plasma membrane / cytoplasm Similarity search - Function Calponin-like domain / EF-hand, Ca insensitive / Ca2+ insensitive EF hand / Ca2+ insensitive EF hand / Actin-binding Protein, T-fimbrin; domain 1 / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. ... Calponin-like domain / EF-hand, Ca insensitive / Ca2+ insensitive EF hand / Ca2+ insensitive EF hand / Actin-binding Protein, T-fimbrin; domain 1 / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. / Spectrin repeats / Actinin-type actin-binding domain, conserved site / Calponin homology domain / Calponin homology (CH) domain / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.37 Å DetailsAuthors Birrane, G. / Feng, D. Funding support United States, 3items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) DK59588 United States National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) DK114329 United States National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) DK007199 United States
CitationJournal : J. Am. Soc. Nephrol. / Year : 2020Title : Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.Authors: Feng, D. / Kumar, M. / Muntel, J. / Gurley, S.B. / Birrane, G. / Stillman, I.E. / Ding, L. / Wang, M. / Ahmed, S. / Schlondorff, J. / Alper, S.L. / Ferrante, T. / Marquez, S.L. / Ng, C.F. / ... Authors : Feng, D. / Kumar, M. / Muntel, J. / Gurley, S.B. / Birrane, G. / Stillman, I.E. / Ding, L. / Wang, M. / Ahmed, S. / Schlondorff, J. / Alper, S.L. / Ferrante, T. / Marquez, S.L. / Ng, C.F. / Novak, R. / Ingber, D.E. / Steen, H. / Pollak, M.R. History Deposition Mar 15, 2019 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 18, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Sep 9, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.journal_abbrev / _citation.journal_id_CSD ... _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Oct 11, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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