登録情報 データベース : PDB / ID : 6o2z 構造の表示 ダウンロードとリンクタイトル Crystal structure of IDH1 R132H mutant in complex with compound 32 要素Isocitrate dehydrogenase [NADP] cytoplasmic 詳細 キーワード Oxidoreductase/Inhibitor / IDH1 / allosteric inhibitor / Oxidoreductase / Inhibitor complex / Oxidoreductase-Inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate / NADPH regeneration / regulation of phospholipid catabolic process / regulation of phospholipid biosynthetic process / NFE2L2 regulating TCA cycle genes / isocitrate metabolic process / isocitrate dehydrogenase (NADP+) / isocitrate dehydrogenase (NADP+) activity / 2-oxoglutarate metabolic process / NADP metabolic process ... Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate / NADPH regeneration / regulation of phospholipid catabolic process / regulation of phospholipid biosynthetic process / NFE2L2 regulating TCA cycle genes / isocitrate metabolic process / isocitrate dehydrogenase (NADP+) / isocitrate dehydrogenase (NADP+) activity / 2-oxoglutarate metabolic process / NADP metabolic process / glyoxylate cycle / response to steroid hormone / female gonad development / peroxisomal matrix / tricarboxylic acid cycle / glutathione metabolic process / Peroxisomal protein import / peroxisome / NAD binding / tertiary granule lumen / NADP binding / secretory granule lumen / ficolin-1-rich granule lumen / response to oxidative stress / cadherin binding / Neutrophil degranulation / magnesium ion binding / protein homodimerization activity / mitochondrion / extracellular exosome / extracellular region / identical protein binding / cytoplasm / cytosol 類似検索 - 分子機能 Isocitrate dehydrogenase NADP-dependent / Isopropylmalate Dehydrogenase / Isopropylmalate Dehydrogenase / Isocitrate/isopropylmalate dehydrogenase, conserved site / Isocitrate and isopropylmalate dehydrogenases signature. / Isopropylmalate dehydrogenase-like domain / Isocitrate/isopropylmalate dehydrogenase / Isocitrate/isopropylmalate dehydrogenase / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 Chem-LJV / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / Isocitrate dehydrogenase [NADP] cytoplasmic 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.5 Å 詳細データ登録者 Toms, A.V. / Lin, J. 引用ジャーナル : J.Med.Chem. / 年 : 2019タイトル : Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors.著者: Lin, J. / Lu, W. / Caravella, J.A. / Campbell, A.M. / Diebold, R.B. / Ericsson, A. / Fritzen, E. / Gustafson, G.R. / Lancia Jr., D.R. / Shelekhin, T. / Wang, Z. / Castro, J. / Clarke, A. / ... 著者 : Lin, J. / Lu, W. / Caravella, J.A. / Campbell, A.M. / Diebold, R.B. / Ericsson, A. / Fritzen, E. / Gustafson, G.R. / Lancia Jr., D.R. / Shelekhin, T. / Wang, Z. / Castro, J. / Clarke, A. / Gotur, D. / Josephine, H.R. / Katz, M. / Diep, H. / Kershaw, M. / Yao, L. / Kauffman, G. / Hubbs, S.E. / Luke, G.P. / Toms, A.V. / Wang, L. / Bair, K.W. / Barr, K.J. / Dinsmore, C. / Walker, D. / Ashwell, S. 履歴 登録 2019年2月25日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2019年6月26日 Provider : repository / タイプ : Initial release改定 1.1 2019年8月7日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.name 改定 1.2 2024年3月13日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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