登録情報 | データベース: PDB / ID: 6no9 |
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タイトル | PIM1 in complex with Cpd16 (5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide) |
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要素 | Serine/threonine-protein kinase pim-1 |
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キーワード | TRANSFERASE / kinase |
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機能・相同性 | 機能・相同性情報
positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / cellular detoxification / vitamin D receptor signaling pathway / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / positive regulation of TORC1 signaling ...positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / cellular detoxification / vitamin D receptor signaling pathway / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / positive regulation of TORC1 signaling / Signaling by FLT3 fusion proteins / negative regulation of innate immune response / positive regulation of brown fat cell differentiation / protein serine/threonine kinase activator activity / regulation of transmembrane transporter activity / positive regulation of protein serine/threonine kinase activity / negative regulation of DNA-binding transcription factor activity / cellular response to type II interferon / manganese ion binding / Interleukin-4 and Interleukin-13 signaling / protein autophosphorylation / protein stabilization / non-specific serine/threonine protein kinase / cell cycle / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / nucleolus / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / nucleoplasm / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Serine/threonine-protein kinase pim-1/2/3 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site ...Serine/threonine-protein kinase pim-1/2/3 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-KUV / PHOSPHATE ION / Serine/threonine-protein kinase pim-1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.712 Å |
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データ登録者 | Murray, J.M. / Noland, C. |
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引用 | ジャーナル: J. Med. Chem. / 年: 2019 タイトル: Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma. 著者: Wang, X. / Blackaby, W. / Allen, V. / Chan, G.K.Y. / Chang, J.H. / Chiang, P.C. / Diene, C. / Drummond, J. / Do, S. / Fan, E. / Harstad, E.B. / Hodges, A. / Hu, H. / Jia, W. / Kofie, W. / ...著者: Wang, X. / Blackaby, W. / Allen, V. / Chan, G.K.Y. / Chang, J.H. / Chiang, P.C. / Diene, C. / Drummond, J. / Do, S. / Fan, E. / Harstad, E.B. / Hodges, A. / Hu, H. / Jia, W. / Kofie, W. / Kolesnikov, A. / Lyssikatos, J.P. / Ly, J. / Matteucci, M. / Moffat, J.G. / Munugalavadla, V. / Murray, J. / Nash, D. / Noland, C.L. / Del Rosario, G. / Ross, L. / Rouse, C. / Sharpe, A. / Slaga, D. / Sun, M. / Tsui, V. / Wallweber, H. / Yu, S.F. / Ebens, A.J. |
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履歴 | 登録 | 2019年1月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年2月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年3月13日 | Group: Data collection / Database references カテゴリ: citation / citation_author / pdbx_database_proc Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.name |
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改定 1.2 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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