+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 6nm8 | ||||||||||||||||||
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タイトル | IgV-V76T BMS compound 105 | ||||||||||||||||||
要素 | Programmed cell death 1 ligand 1 | ||||||||||||||||||
キーワード | immune system/inhibitor / Fragment-based screening / Structure-based design / PD-L1 inhibitor / Cancer drug discovery / Immunotherapy / IMMUNE SYSTEM / immune system-inhibitor complex | ||||||||||||||||||
機能・相同性 | 機能・相同性情報 negative regulation of tumor necrosis factor superfamily cytokine production / positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process / negative regulation of CD8-positive, alpha-beta T cell activation / negative regulation of T cell mediated immune response to tumor cell / TRIF-dependent toll-like receptor signaling pathway / negative regulation of CD4-positive, alpha-beta T cell proliferation / STAT3 nuclear events downstream of ALK signaling / negative regulation of interleukin-10 production / negative regulation of activated T cell proliferation / positive regulation of interleukin-10 production ...negative regulation of tumor necrosis factor superfamily cytokine production / positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process / negative regulation of CD8-positive, alpha-beta T cell activation / negative regulation of T cell mediated immune response to tumor cell / TRIF-dependent toll-like receptor signaling pathway / negative regulation of CD4-positive, alpha-beta T cell proliferation / STAT3 nuclear events downstream of ALK signaling / negative regulation of interleukin-10 production / negative regulation of activated T cell proliferation / positive regulation of interleukin-10 production / negative regulation of type II interferon production / PD-1 signaling / positive regulation of T cell proliferation / T cell costimulation / response to cytokine / recycling endosome membrane / actin cytoskeleton / early endosome membrane / cellular response to lipopolysaccharide / adaptive immune response / transcription coactivator activity / cell surface receptor signaling pathway / receptor ligand activity / positive regulation of cell migration / immune response / external side of plasma membrane / signal transduction / extracellular exosome / nucleoplasm / plasma membrane 類似検索 - 分子機能 | ||||||||||||||||||
生物種 | Homo sapiens (ヒト) | ||||||||||||||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.792 Å | ||||||||||||||||||
データ登録者 | Perry, E. / Zhao, B. / Fesik, S. | ||||||||||||||||||
資金援助 | 米国, 5件
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引用 | ジャーナル: Bioorg. Med. Chem. Lett. / 年: 2019 タイトル: Fragment-based screening of programmed death ligand 1 (PD-L1). 著者: Perry, E. / Mills, J.J. / Zhao, B. / Wang, F. / Sun, Q. / Christov, P.P. / Tarr, J.C. / Rietz, T.A. / Olejniczak, E.T. / Lee, T. / Fesik, S. | ||||||||||||||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 6nm8.cif.gz | 66.6 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb6nm8.ent.gz | 46.5 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 6nm8.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
文書・要旨 | 6nm8_validation.pdf.gz | 699.2 KB | 表示 | wwPDB検証レポート |
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文書・詳細版 | 6nm8_full_validation.pdf.gz | 702 KB | 表示 | |
XML形式データ | 6nm8_validation.xml.gz | 11.7 KB | 表示 | |
CIF形式データ | 6nm8_validation.cif.gz | 14.7 KB | 表示 | |
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/nm/6nm8 ftp://data.pdbj.org/pub/pdb/validation_reports/nm/6nm8 | HTTPS FTP |
-関連構造データ
-リンク
-集合体
登録構造単位 |
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単位格子 |
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非結晶学的対称性 (NCS) | NCSドメイン:
NCSドメイン領域: Ens-ID: 1
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