+Open data
-Basic information
Entry | Database: PDB / ID: 6nm8 | ||||||||||||||||||
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Title | IgV-V76T BMS compound 105 | ||||||||||||||||||
Components | Programmed cell death 1 ligand 1 | ||||||||||||||||||
Keywords | immune system/inhibitor / Fragment-based screening / Structure-based design / PD-L1 inhibitor / Cancer drug discovery / Immunotherapy / IMMUNE SYSTEM / immune system-inhibitor complex | ||||||||||||||||||
Function / homology | Function and homology information negative regulation of tumor necrosis factor superfamily cytokine production / positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process / negative regulation of CD8-positive, alpha-beta T cell activation / negative regulation of T cell mediated immune response to tumor cell / TRIF-dependent toll-like receptor signaling pathway / negative regulation of CD4-positive, alpha-beta T cell proliferation / STAT3 nuclear events downstream of ALK signaling / negative regulation of interleukin-10 production / negative regulation of activated T cell proliferation / positive regulation of interleukin-10 production ...negative regulation of tumor necrosis factor superfamily cytokine production / positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process / negative regulation of CD8-positive, alpha-beta T cell activation / negative regulation of T cell mediated immune response to tumor cell / TRIF-dependent toll-like receptor signaling pathway / negative regulation of CD4-positive, alpha-beta T cell proliferation / STAT3 nuclear events downstream of ALK signaling / negative regulation of interleukin-10 production / negative regulation of activated T cell proliferation / positive regulation of interleukin-10 production / negative regulation of type II interferon production / PD-1 signaling / positive regulation of T cell proliferation / T cell costimulation / response to cytokine / recycling endosome membrane / actin cytoskeleton / early endosome membrane / cellular response to lipopolysaccharide / adaptive immune response / transcription coactivator activity / cell surface receptor signaling pathway / receptor ligand activity / positive regulation of cell migration / immune response / external side of plasma membrane / signal transduction / extracellular exosome / nucleoplasm / plasma membrane Similarity search - Function | ||||||||||||||||||
Biological species | Homo sapiens (human) | ||||||||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.792 Å | ||||||||||||||||||
Authors | Perry, E. / Zhao, B. / Fesik, S. | ||||||||||||||||||
Funding support | United States, 5items
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Citation | Journal: Bioorg. Med. Chem. Lett. / Year: 2019 Title: Fragment-based screening of programmed death ligand 1 (PD-L1). Authors: Perry, E. / Mills, J.J. / Zhao, B. / Wang, F. / Sun, Q. / Christov, P.P. / Tarr, J.C. / Rietz, T.A. / Olejniczak, E.T. / Lee, T. / Fesik, S. | ||||||||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6nm8.cif.gz | 66.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6nm8.ent.gz | 46.5 KB | Display | PDB format |
PDBx/mmJSON format | 6nm8.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6nm8_validation.pdf.gz | 699.2 KB | Display | wwPDB validaton report |
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Full document | 6nm8_full_validation.pdf.gz | 702 KB | Display | |
Data in XML | 6nm8_validation.xml.gz | 11.7 KB | Display | |
Data in CIF | 6nm8_validation.cif.gz | 14.7 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/nm/6nm8 ftp://data.pdbj.org/pub/pdb/validation_reports/nm/6nm8 | HTTPS FTP |
-Related structure data
Related structure data | 6nm7C 6nnvC 6nojC 6nosC 6np9SC S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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