登録情報 | データベース: PDB / ID: 6nfz |
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タイトル | Crystal structure of diphosphorylated HPK1 kinase domain in complex with sunitinib in the active state. |
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要素 | Mitogen-activated protein kinase kinase kinase kinase 1 |
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キーワード | SIGNALING PROTEIN / Kinase / active state / dimer |
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機能・相同性 | 機能・相同性情報
MAP kinase kinase kinase kinase activity / cellular response to phorbol 13-acetate 12-myristate / JNK cascade / peptidyl-serine phosphorylation / cell population proliferation / positive regulation of MAPK cascade / protein autophosphorylation / non-specific serine/threonine protein kinase / intracellular signal transduction / protein phosphorylation ...MAP kinase kinase kinase kinase activity / cellular response to phorbol 13-acetate 12-myristate / JNK cascade / peptidyl-serine phosphorylation / cell population proliferation / positive regulation of MAPK cascade / protein autophosphorylation / non-specific serine/threonine protein kinase / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / ATP binding / membrane / cytoplasm類似検索 - 分子機能 Mitogen-activated protein (MAP) kinase kinase kinase kinase / Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 / CNH domain / Citron homology (CNH) domain / Citron homology (CNH) domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain ...Mitogen-activated protein (MAP) kinase kinase kinase kinase / Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 / CNH domain / Citron homology (CNH) domain / Citron homology (CNH) domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-B49 / Mitogen-activated protein kinase kinase kinase kinase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.966 Å |
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データ登録者 | Johnson, E. / McTigue, M. / Cronin, C.N. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2019 タイトル: Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation. 著者: Johnson, E. / McTigue, M. / Gallego, R.A. / Johnson, T.W. / Timofeevski, S. / Maestre, M. / Fisher, T.S. / Kania, R. / Sawasdikosol, S. / Burakoff, S. / Cronin, C.N. |
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履歴 | 登録 | 2018年12月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年5月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年5月8日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2019年6月19日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2019年6月26日 | Group: Data collection / Database references / カテゴリ: citation_author / Item: _citation_author.identifier_ORCID |
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