登録情報 | データベース: PDB / ID: 6myd |
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タイトル | Structure of zebrafish TRAF6 in complex with STING CTT |
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要素 | - STING CTT, Transmembrane protein 173
- TNF receptor-associated factor 6
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キーワード | IMMUNE SYSTEM / Innate Immunity / STING / NF-kappaB / TRAF6 / TMEM173 |
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機能・相同性 | 機能・相同性情報
STING mediated induction of host immune responses / STAT6-mediated induction of chemokines / Regulation of innate immune responses to cytosolic DNA / p75NTR recruits signalling complexes / Interleukin-1 signaling / NOD1/2 Signaling Pathway / Ovarian tumor domain proteases / Ub-specific processing proteases / Neutrophil degranulation / regulation of type I interferon production ...STING mediated induction of host immune responses / STAT6-mediated induction of chemokines / Regulation of innate immune responses to cytosolic DNA / p75NTR recruits signalling complexes / Interleukin-1 signaling / NOD1/2 Signaling Pathway / Ovarian tumor domain proteases / Ub-specific processing proteases / Neutrophil degranulation / regulation of type I interferon production / proton channel activity / 2',3'-cyclic GMP-AMP binding / cGAS/STING signaling pathway / cyclic-di-GMP binding / tumor necrosis factor receptor binding / regulation of canonical NF-kappaB signal transduction / cytoplasmic pattern recognition receptor signaling pathway / reticulophagy / non-canonical NF-kappaB signal transduction / positive regulation of type I interferon production / protein K63-linked ubiquitination / autophagosome membrane / positive regulation of macroautophagy / autophagosome assembly / positive regulation of defense response to virus by host / lipopolysaccharide-mediated signaling pathway / activation of innate immune response / tumor necrosis factor-mediated signaling pathway / endoplasmic reticulum-Golgi intermediate compartment membrane / autophagosome / lipid droplet / regulation of autophagy / response to bacterium / RING-type E3 ubiquitin transferase / response to virus / positive regulation of non-canonical NF-kappaB signal transduction / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / cell cortex / cytoplasmic vesicle / defense response to virus / regulation of apoptotic process / Golgi membrane / innate immune response / endoplasmic reticulum membrane / perinuclear region of cytoplasm / positive regulation of DNA-templated transcription / endoplasmic reticulum / zinc ion binding / nucleus / cytoplasm類似検索 - 分子機能 TNF receptor-associated factor 6 / TNF receptor-associated factor 6, MATH domain / : / TRAF-type zinc finger / TRAF/meprin, MATH domain / TNF receptor-associated factor TRAF, metazoa / Zinc finger, TRAF-type / Zinc finger TRAF-type profile. / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A ...TNF receptor-associated factor 6 / TNF receptor-associated factor 6, MATH domain / : / TRAF-type zinc finger / TRAF/meprin, MATH domain / TNF receptor-associated factor TRAF, metazoa / Zinc finger, TRAF-type / Zinc finger TRAF-type profile. / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / : / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / Transmembrane protein 173 / MATH/TRAF domain / MATH/TRAF domain profile. / meprin and TRAF homology / TRAF-like / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 Stimulator of interferon genes protein / TNF receptor-associated factor 6類似検索 - 構成要素 |
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生物種 | Danio rerio (ゼブラフィッシュ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.399 Å |
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データ登録者 | de Oliveira Mann, C.C. / Orzalli, M.H. / King, D.S. / Kagan, J.C. / Lee, A.S.Y. / Kranzusch, P.J. |
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引用 | ジャーナル: Cell Rep / 年: 2019 タイトル: Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-kappa B Signaling Adaptation. 著者: de Oliveira Mann, C.C. / Orzalli, M.H. / King, D.S. / Kagan, J.C. / Lee, A.S.Y. / Kranzusch, P.J. |
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履歴 | 登録 | 2018年11月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年5月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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