Entry | Database: PDB / ID: 6m6e |
---|
Title | Solution structure of the core domain of Fibroblast growth factor 21 (FGF21) |
---|
Components | Fibroblast growth factor 21 |
---|
Keywords | HORMONE / Anti-diabetes / beta-trefoil conformation / beta-klotho binding / Metabolic regulator |
---|
Function / homology | Function and homology information
positive regulation of triglyceride catabolic process / Cellular hexose transport / response to methionine / Assembly of active LPL and LIPC lipase complexes / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway / regulation of low-density lipoprotein particle clearance / fibroblast growth factor receptor binding / endothelial cell apoptotic process / positive regulation of low-density lipoprotein receptor activity / cellular response to glucagon stimulus ...positive regulation of triglyceride catabolic process / Cellular hexose transport / response to methionine / Assembly of active LPL and LIPC lipase complexes / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway / regulation of low-density lipoprotein particle clearance / fibroblast growth factor receptor binding / endothelial cell apoptotic process / positive regulation of low-density lipoprotein receptor activity / cellular response to glucagon stimulus / cellular response to low-density lipoprotein particle stimulus / fibroblast growth factor receptor signaling pathway / negative regulation of endothelial cell apoptotic process / endoplasmic reticulum unfolded protein response / regulation of cell migration / response to nutrient levels / response to activity / positive regulation of glucose import / cellular response to glucose stimulus / animal organ morphogenesis / growth factor activity / cellular response to xenobiotic stimulus / cell-cell signaling / positive regulation of cold-induced thermogenesis / positive regulation of ERK1 and ERK2 cascade / cell differentiation / positive regulation of protein phosphorylation / positive regulation of cell population proliferation / positive regulation of gene expression / signal transduction / extracellular space / extracellular region / cytoplasmSimilarity search - Function Fibroblast growth factor 15/19/21 / HBGF/FGF family signature. / Fibroblast growth factor family / Fibroblast growth factor / Acidic and basic fibroblast growth factor family. / Cytokine IL1/FGFSimilarity search - Domain/homology |
---|
Biological species | Homo sapiens (human) |
---|
Method | SOLUTION NMR / simulated annealing |
---|
Authors | Zhu, L. / Zhao, H. / Wang, J. |
---|
Funding support | China, 2items Organization | Grant number | Country |
---|
National Natural Science Foundation of China (NSFC) | U1532269 | China | National Natural Science Foundation of China (NSFC) | 31100539 | China |
|
---|
Citation | Journal: Embo Rep. / Year: 2021 Title: Dynamic folding modulation generates FGF21 variant against diabetes. Authors: Zhu, L. / Zhao, H. / Liu, J. / Cai, H. / Wu, B. / Liu, Z. / Zhou, S. / Liu, Q. / Li, X. / Bao, B. / Liu, J. / Dai, H. / Wang, J. |
---|
History | Deposition | Mar 14, 2020 | Deposition site: PDBJ / Processing site: PDBJ |
---|
Revision 1.0 | Jan 20, 2021 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Mar 3, 2021 | Group: Database references / Category: citation / Item: _citation.journal_volume / _citation.year |
---|
Revision 1.2 | Jun 14, 2023 | Group: Database references / Other / Category: database_2 / pdbx_database_status Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data |
---|
|
---|