- PDB-6le5: Crystal structure of the mitochondrial calcium uptake 1 and 2 het... -
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Basic information
Entry
Database: PDB / ID: 6le5
Title
Crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1-MICU2 heterodimer) in an apo state
Components
Calcium uptake protein 1, mitochondrial
Calcium uptake protein 2, mitochondrial
Keywords
METAL BINDING PROTEIN / Complex / Mitochondrial calcium uptake 1 and mitochondrial calcium uptake 2
Function / homology
Function and homology information
negative regulation of mitochondrial calcium ion concentration / regulation of cellular hyperosmotic salinity response / Processing of SMDT1 / mitochondrial calcium ion transmembrane transport / uniplex complex / Mitochondrial calcium ion transport / calcium import into the mitochondrion / positive regulation of mitochondrial calcium ion concentration / mitochondrial calcium ion homeostasis / calcium ion import ...negative regulation of mitochondrial calcium ion concentration / regulation of cellular hyperosmotic salinity response / Processing of SMDT1 / mitochondrial calcium ion transmembrane transport / uniplex complex / Mitochondrial calcium ion transport / calcium import into the mitochondrion / positive regulation of mitochondrial calcium ion concentration / mitochondrial calcium ion homeostasis / calcium ion import / Mitochondrial protein degradation / calcium channel complex / mitochondrial membrane / protein homooligomerization / mitochondrial intermembrane space / defense response / mitochondrial inner membrane / protein heterodimerization activity / calcium ion binding / mitochondrion / identical protein binding Similarity search - Function
Method to determine structure: SAD / Resolution: 3.1→50.01 Å / Cor.coef. Fo:Fc: 0.865 / Cor.coef. Fo:Fc free: 0.85 / Cross valid method: THROUGHOUT / ESU R Free: 0.59 / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.33162
2802
4.9 %
RANDOM
Rwork
0.29277
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obs
0.29467
54709
99.92 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å