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Yorodumi- PDB-6l6l: Structural basis of NR4A2 homodimers binding to selective Nur-res... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6l6l | |||||||||
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Title | Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements | |||||||||
Components |
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Keywords | DNA BINDING PROTEIN / NR4A2/Nurr1 / nuclear receptors | |||||||||
Function / homology | Function and homology information general adaptation syndrome / habenula development / central nervous system neuron differentiation / cellular response to corticotropin-releasing hormone stimulus / central nervous system projection neuron axonogenesis / regulation of dopamine metabolic process / : / midbrain dopaminergic neuron differentiation / nuclear glucocorticoid receptor binding / regulation of respiratory gaseous exchange ...general adaptation syndrome / habenula development / central nervous system neuron differentiation / cellular response to corticotropin-releasing hormone stimulus / central nervous system projection neuron axonogenesis / regulation of dopamine metabolic process / : / midbrain dopaminergic neuron differentiation / nuclear glucocorticoid receptor binding / regulation of respiratory gaseous exchange / dopaminergic neuron differentiation / neuron maturation / dopamine biosynthetic process / positive regulation of catalytic activity / fat cell differentiation / negative regulation of apoptotic signaling pathway / canonical Wnt signaling pathway / nuclear retinoid X receptor binding / response to amphetamine / adult locomotory behavior / post-embryonic development / neuron migration / SUMOylation of intracellular receptors / beta-catenin binding / Nuclear Receptor transcription pathway / nuclear receptor activity / sequence-specific double-stranded DNA binding / cellular response to oxidative stress / DNA-binding transcription activator activity, RNA polymerase II-specific / neuron apoptotic process / negative regulation of neuron apoptotic process / transcription regulator complex / transcription by RNA polymerase II / response to hypoxia / DNA-binding transcription factor activity, RNA polymerase II-specific / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein heterodimerization activity / DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / zinc ion binding / nucleoplasm / nucleus / cytoplasm Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.781 Å | |||||||||
Authors | Jiang, L. / Chen, Y. | |||||||||
Funding support | China, 2items
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Citation | Journal: J.Biol.Chem. / Year: 2019 Title: Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements. Authors: Jiang, L. / Dai, S. / Li, J. / Liang, X. / Qu, L. / Chen, X. / Guo, M. / Chen, Z. / Chen, L. / Wei, H. / Chen, Y. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6l6l.cif.gz | 130.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6l6l.ent.gz | 97.6 KB | Display | PDB format |
PDBx/mmJSON format | 6l6l.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/l6/6l6l ftp://data.pdbj.org/pub/pdb/validation_reports/l6/6l6l | HTTPS FTP |
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-Related structure data
Related structure data | 6l6qC 1citS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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