+Open data
-Basic information
Entry | Database: PDB / ID: 6l50 | ||||||||||||
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Title | Crystal structure of Zika NS2B-NS3 protease with compound 16 | ||||||||||||
Components |
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Keywords | VIRAL PROTEIN / Viral protease / Protease inhibitor complex | ||||||||||||
Function / homology | Function and homology information flavivirin / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / ribonucleoside triphosphate phosphatase activity / double-stranded RNA binding / nucleoside-triphosphate phosphatase / viral capsid / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity / symbiont-mediated suppression of host toll-like receptor signaling pathway ...flavivirin / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / ribonucleoside triphosphate phosphatase activity / double-stranded RNA binding / nucleoside-triphosphate phosphatase / viral capsid / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity / symbiont-mediated suppression of host toll-like receptor signaling pathway / mRNA (guanine-N7)-methyltransferase / methyltransferase cap1 / clathrin-dependent endocytosis of virus by host cell / mRNA (nucleoside-2'-O-)-methyltransferase activity / mRNA 5'-cap (guanine-N7-)-methyltransferase activity / RNA helicase activity / host cell perinuclear region of cytoplasm / protein dimerization activity / host cell endoplasmic reticulum membrane / RNA helicase / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / symbiont-mediated suppression of host innate immune response / induction by virus of host autophagy / symbiont entry into host cell / RNA-directed RNA polymerase / viral RNA genome replication / serine-type endopeptidase activity / RNA-dependent RNA polymerase activity / virus-mediated perturbation of host defense response / fusion of virus membrane with host endosome membrane / lipid binding / viral envelope / host cell nucleus / GTP binding / virion attachment to host cell / structural molecule activity / virion membrane / ATP hydrolysis activity / proteolysis / extracellular region / ATP binding / membrane / metal ion binding Similarity search - Function | ||||||||||||
Biological species | Zika virus | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.95 Å | ||||||||||||
Authors | Quek, J.P. | ||||||||||||
Funding support | Singapore, 3items
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Citation | Journal: Antiviral Res. / Year: 2020 Title: Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease. Authors: Quek, J.P. / Liu, S. / Zhang, Z. / Li, Y. / Ng, E.Y. / Loh, Y.R. / Hung, A.W. / Luo, D. / Kang, C. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6l50.cif.gz | 298.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6l50.ent.gz | 240.8 KB | Display | PDB format |
PDBx/mmJSON format | 6l50.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6l50_validation.pdf.gz | 785.6 KB | Display | wwPDB validaton report |
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Full document | 6l50_full_validation.pdf.gz | 808 KB | Display | |
Data in XML | 6l50_validation.xml.gz | 28.9 KB | Display | |
Data in CIF | 6l50_validation.cif.gz | 39.3 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/l5/6l50 ftp://data.pdbj.org/pub/pdb/validation_reports/l5/6l50 | HTTPS FTP |
-Related structure data
Related structure data | 6l4zC 5gpiS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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