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Yorodumi- PDB-6kn9: Crystal structure of human interleukin 18 receptor beta extracell... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6kn9 | |||||||||
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Title | Crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scFv | |||||||||
Components |
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Keywords | CYTOKINE / Interleukin receptor / antibody / complex / antagonist | |||||||||
Function / homology | Function and homology information interleukin-18 receptor activity / interleukin-18 receptor complex / Interleukin-18 signaling / positive regulation of natural killer cell mediated cytotoxicity / neutrophil activation / interleukin-18-mediated signaling pathway / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase / NAD+ nucleosidase activity / NAD+ nucleotidase, cyclic ADP-ribose generating / coreceptor activity ...interleukin-18 receptor activity / interleukin-18 receptor complex / Interleukin-18 signaling / positive regulation of natural killer cell mediated cytotoxicity / neutrophil activation / interleukin-18-mediated signaling pathway / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase / NAD+ nucleosidase activity / NAD+ nucleotidase, cyclic ADP-ribose generating / coreceptor activity / cellular response to hydrogen peroxide / positive regulation of NF-kappaB transcription factor activity / cell population proliferation / inflammatory response / immune response / plasma membrane Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.302 Å | |||||||||
Authors | Wu, D.H. / Liu, C.C. | |||||||||
Funding support | China, 2items
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Citation | Journal: J.Mol.Biol. / Year: 2020 Title: A Synthetic Human Antibody Antagonizes IL-18R beta Signaling Through an Allosteric Mechanism. Authors: Liu, S. / Miersch, S. / Li, P. / Bai, B.X, / Liu, C.C. / Qin, W.M. / Su, J. / Huang, H.M. / Pan, J. / Sidhu, S.S. / Wu, D.H. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6kn9.cif.gz | 266.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6kn9.ent.gz | 204.8 KB | Display | PDB format |
PDBx/mmJSON format | 6kn9.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6kn9_validation.pdf.gz | 1.3 MB | Display | wwPDB validaton report |
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Full document | 6kn9_full_validation.pdf.gz | 1.3 MB | Display | |
Data in XML | 6kn9_validation.xml.gz | 48.4 KB | Display | |
Data in CIF | 6kn9_validation.cif.gz | 66.3 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/kn/6kn9 ftp://data.pdbj.org/pub/pdb/validation_reports/kn/6kn9 | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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