Entry | Database: PDB / ID: 6jw9 |
---|
Title | Crystal structure of E-64 inhibited falcipain 2 from Plasmodium falciparum, strain 3D7 |
---|
Components | Cysteine protease falcipain-2 |
---|
Keywords | HYDROLASE / Cysteine protease / haemoglobinase / drug-target / Plasmodium falciparum |
---|
Function / homology | Function and homology information
MHC class II antigen presentation / Neutrophil degranulation / food vacuole / proteolysis involved in protein catabolic process / Hydrolases; Acting on peptide bonds (peptidases); Cysteine endopeptidases / cysteine-type endopeptidase activity / proteolysis / extracellular space / membraneSimilarity search - Function Cathepsin propeptide inhibitor domain (I29) / Cathepsin propeptide inhibitor domain (I29) / Cathepsin propeptide inhibitor domain (I29) / Papain-like cysteine endopeptidase / : / Cysteine peptidase, histidine active site / Eukaryotic thiol (cysteine) proteases histidine active site. / Peptidase C1A, papain C-terminal / Papain family cysteine protease / Papain family cysteine protease ...Cathepsin propeptide inhibitor domain (I29) / Cathepsin propeptide inhibitor domain (I29) / Cathepsin propeptide inhibitor domain (I29) / Papain-like cysteine endopeptidase / : / Cysteine peptidase, histidine active site / Eukaryotic thiol (cysteine) proteases histidine active site. / Peptidase C1A, papain C-terminal / Papain family cysteine protease / Papain family cysteine protease / Cysteine proteinases / Cysteine peptidase, cysteine active site / Eukaryotic thiol (cysteine) proteases cysteine active site. / Cathepsin B; Chain A / Papain-like cysteine peptidase superfamily / Alpha-Beta Complex / Alpha BetaSimilarity search - Domain/homology |
---|
Biological species | ![](img/tx_eukaryote.gif) Plasmodium falciparum (malaria parasite P. falciparum) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.5 Å |
---|
Authors | Chakraborty, S. / Alam, B. / Biswas, S. |
---|
Citation | Journal: Biochem.Biophys.Res.Commun. / Year: 2022 Title: New insights of falcipain 2 structure from Plasmodium falciparum 3D7 strain. Authors: Chakraborty, S. / Alam, B. / Biswas, S. |
---|
History | Deposition | Apr 18, 2019 | Deposition site: PDBJ / Processing site: PDBJ |
---|
Revision 1.0 | Apr 22, 2020 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Oct 19, 2022 | Group: Database references / Category: citation / database_2 Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
Revision 1.2 | Nov 29, 2023 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id ..._struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
---|
|
---|