Entry Database : PDB / ID : 6jmu Structure visualization Downloads & linksTitle Crystal structure of GIT1/Paxillin complex ComponentsARF GTPase-activating protein GIT1 Paxillin DetailsKeywords CELL ADHESION / GIT1 / Paxillin / ComplexFunction / homology Function and homology informationFunction Domain/homology Component
BH4 domain binding / Regulation of cytoskeletal remodeling and cell spreading by IPP complex components / negative regulation of ARF protein signal transduction / Localization of the PINCH-ILK-PARVIN complex to focal adhesions / structural constituent of postsynaptic specialization / Ephrin signaling / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / GAB1 signalosome / response to peptide / motor learning ... BH4 domain binding / Regulation of cytoskeletal remodeling and cell spreading by IPP complex components / negative regulation of ARF protein signal transduction / Localization of the PINCH-ILK-PARVIN complex to focal adhesions / structural constituent of postsynaptic specialization / Ephrin signaling / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / GAB1 signalosome / response to peptide / motor learning / Smooth Muscle Contraction / negative regulation of inflammatory response to wounding / intramembranous ossification / immunological synapse formation / positive regulation of microtubule nucleation / dendritic spine development / vinculin binding / neuropilin binding / MAP-kinase scaffold activity / regulation of G protein-coupled receptor signaling pathway / VEGFA-VEGFR2 Pathway / gamma-tubulin binding / focal adhesion assembly / negative regulation of glycolytic process / neurotransmitter receptor localization to postsynaptic specialization membrane / negative regulation of interleukin-1 beta production / growth hormone receptor signaling pathway / lamellipodium assembly / regulation of synaptic vesicle exocytosis / branching morphogenesis of an epithelial tube / positive regulation of receptor catabolic process / cell leading edge / mitotic spindle pole / calyx of Held / endothelial cell migration / GABA-ergic synapse / neuron development / ephrin receptor signaling pathway / positive regulation of protein kinase activity / stress fiber / positive regulation of stress fiber assembly / cellular response to epidermal growth factor stimulus / cytoskeleton organization / presynaptic modulation of chemical synaptic transmission / substrate adhesion-dependent cell spreading / GTPase activator activity / transforming growth factor beta receptor signaling pathway / regulation of cytokinesis / cell redox homeostasis / locomotory behavior / integrin-mediated signaling pathway / transcription coregulator activity / brain development / beta-catenin binding / small GTPase binding / peptidyl-tyrosine phosphorylation / positive regulation of angiogenesis / cell-cell junction / signaling receptor complex adaptor activity / cell migration / integrin binding / lamellipodium / cell cortex / regulation of cell shape / postsynapse / cellular response to lipopolysaccharide / protein phosphatase binding / endosome / neuron projection / focal adhesion / centrosome / glutamatergic synapse / synapse / protein-containing complex binding / protein kinase binding / mitochondrion / identical protein binding / metal ion binding / plasma membrane / cytosol Similarity search - Function Arf GTPase-activating protein GIT1/2, coiled-coil domain / GIT coiled-coil Rho guanine nucleotide exchange factor / ARF GTPase-activating protein GIT1, C-terminal / G protein-coupled receptor kinase-interacting protein 1 C term / GIT, Spa2 homology (SHD) domain / Spa2 homology domain (SHD) of GIT / Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins / Paxillin / : / : ... Arf GTPase-activating protein GIT1/2, coiled-coil domain / GIT coiled-coil Rho guanine nucleotide exchange factor / ARF GTPase-activating protein GIT1, C-terminal / G protein-coupled receptor kinase-interacting protein 1 C term / GIT, Spa2 homology (SHD) domain / Spa2 homology domain (SHD) of GIT / Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins / Paxillin / : / : / Paxillin family / Arf GTPase activating protein / ArfGAP domain superfamily / Putative GTPase activating protein for Arf / ARF GTPase-activating proteins domain profile. / Putative GTP-ase activating proteins for the small GTPase, ARF / Nucleotidyltransferases domain 2 / ARFGAP/RecO-like zinc finger / Domain of unknown function DUF3447 / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / Four Helix Bundle (Hemerythrin (Met), subunit A) / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Zhu, J. / Lin, L. / Xia, Y. / Zhang, R. / Zhang, M. CitationJournal : Mol.Cell / Year : 2020Title : GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.Authors : Zhu, J. / Zhou, Q. / Xia, Y. / Lin, L. / Li, J. / Peng, M. / Zhang, R. / Zhang, M. History Deposition Mar 13, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 May 20, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Oct 21, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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