登録情報 | データベース: PDB / ID: 6jkg |
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タイトル | The NAD+-free form of human NSDHL |
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要素 | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating |
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キーワード | OXIDOREDUCTASE / Cholesterol / dehydrogenase |
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機能・相同性 | 機能・相同性情報
3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) / C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity / sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity / 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity / 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity / 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity / 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity / Cholesterol biosynthesis / oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor / hair follicle development ...3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) / C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity / sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity / 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity / 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity / 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity / 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity / Cholesterol biosynthesis / oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor / hair follicle development / labyrinthine layer blood vessel development / smoothened signaling pathway / cholesterol biosynthetic process / cholesterol metabolic process / lipid droplet / endoplasmic reticulum membrane / endoplasmic reticulum類似検索 - 分子機能 3-beta hydroxysteroid dehydrogenase/isomerase / 3-beta hydroxysteroid dehydrogenase/isomerase family / NAD(P)-binding domain superfamily類似検索 - ドメイン・相同性 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.9 Å |
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データ登録者 | Kim, D. / Lee, S.J. / Lee, B. |
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資金援助 | 韓国, 3件 組織 | 認可番号 | 国 |
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National Research Foundation (Korea) | NRF-2016R1C1B2014609 | 韓国 | National Research Foundation (Korea) | NRF-2018R1A2A1A19018526 | 韓国 | National Research Foundation (Korea) | NRF-2018R1A5A2024425 | 韓国 |
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引用 | ジャーナル: Cell.Mol.Life Sci. / 年: 2021 タイトル: Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity. 著者: Kim, D.G. / Cho, S. / Lee, K.Y. / Cheon, S.H. / Yoon, H.J. / Lee, J.Y. / Kim, D. / Shin, K.S. / Koh, C.H. / Koo, J.S. / Choi, Y. / Lee, H.H. / Oh, Y.K. / Jeong, Y.S. / Chung, S.J. / Baek, M. ...著者: Kim, D.G. / Cho, S. / Lee, K.Y. / Cheon, S.H. / Yoon, H.J. / Lee, J.Y. / Kim, D. / Shin, K.S. / Koh, C.H. / Koo, J.S. / Choi, Y. / Lee, H.H. / Oh, Y.K. / Jeong, Y.S. / Chung, S.J. / Baek, M. / Jung, K.Y. / Lim, H.J. / Kim, H.S. / Park, S.J. / Lee, J.Y. / Lee, S.J. / Lee, B.J. |
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履歴 | 登録 | 2019年2月28日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2020年3月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年3月18日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2021年2月24日 | Group: Database references / Structure summary / カテゴリ: citation / citation_author / struct Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _citation_author.identifier_ORCID / _struct.title |
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改定 1.3 | 2023年11月22日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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