登録情報 | データベース: PDB / ID: 6jfk |
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タイトル | GDP bound Mitofusin2 (MFN2) |
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要素 | Mitofusin-2,cDNA FLJ57997, highly similar to Transmembrane GTPase MFN2 |
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キーワード | MEMBRANE PROTEIN / mitochondriral fusion / GTPase activity / CMT2A |
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機能・相同性 | 機能・相同性情報
RHOT2 GTPase cycle / parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization / mitochondrion localization / positive regulation of vascular associated smooth muscle cell apoptotic process / camera-type eye morphogenesis / protein localization to phagophore assembly site / protein targeting to mitochondrion / negative regulation of Ras protein signal transduction / blastocyst formation / mitochondrial membrane organization ...RHOT2 GTPase cycle / parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization / mitochondrion localization / positive regulation of vascular associated smooth muscle cell apoptotic process / camera-type eye morphogenesis / protein localization to phagophore assembly site / protein targeting to mitochondrion / negative regulation of Ras protein signal transduction / blastocyst formation / mitochondrial membrane organization / mitochondrial fusion / response to unfolded protein / positive regulation of vascular associated smooth muscle cell proliferation / PINK1-PRKN Mediated Mitophagy / negative regulation of smooth muscle cell proliferation / 加水分解酵素; 酸無水物に作用; GTPに作用・細胞または細胞小器官の運動に関与 / aerobic respiration / microtubule cytoskeleton / Factors involved in megakaryocyte development and platelet production / positive regulation of cold-induced thermogenesis / mitochondrial outer membrane / GTPase activity / ubiquitin protein ligase binding / GTP binding / apoptotic process / mitochondrion / cytosol類似検索 - 分子機能 Mitofusin-2 / Fzo/mitofusin HR2 domain / fzo-like conserved region / Mitofusin family / Dynamin-type guanine nucleotide-binding (G) domain / Dynamin-type guanine nucleotide-binding (G) domain profile. / Dynamin, N-terminal / Dynamin family / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 CITRIC ACID / GUANOSINE-5'-DIPHOSPHATE / cDNA FLJ57997, highly similar to Transmembrane GTPase MFN2 / Mitofusin-2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.997 Å |
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データ登録者 | Li, Y.J. / Cao, Y.L. / Feng, J.X. / Qi, Y.B. / Meng, S.X. / Yang, J.F. / Zhong, Y.T. / Kang, S.S. / Chen, X.X. / Lan, L. ...Li, Y.J. / Cao, Y.L. / Feng, J.X. / Qi, Y.B. / Meng, S.X. / Yang, J.F. / Zhong, Y.T. / Kang, S.S. / Chen, X.X. / Lan, L. / Luo, L. / Yu, B. / Chen, S.D. / Chan, D.C. / Hu, J.J. / Gao, S. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China | | 中国 |
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引用 | ジャーナル: Nat Commun / 年: 2019 タイトル: Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. 著者: Li, Y.J. / Cao, Y.L. / Feng, J.X. / Qi, Y. / Meng, S. / Yang, J.F. / Zhong, Y.T. / Kang, S. / Chen, X. / Lan, L. / Luo, L. / Yu, B. / Chen, S. / Chan, D.C. / Hu, J. / Gao, S. |
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履歴 | 登録 | 2019年2月10日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2019年11月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年11月27日 | Group: Derived calculations カテゴリ: pdbx_struct_assembly / pdbx_struct_assembly_gen ...pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / pdbx_struct_oper_list Item: _pdbx_struct_assembly.details / _pdbx_struct_assembly.method_details ..._pdbx_struct_assembly.details / _pdbx_struct_assembly.method_details / _pdbx_struct_assembly.oligomeric_count / _pdbx_struct_assembly.oligomeric_details |
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改定 1.2 | 2023年11月22日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.3 | 2024年3月20日 | Group: Source and taxonomy / カテゴリ: pdbx_entity_src_syn |
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