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Structure paper

TitleStructural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset.
Journal, issue, pagesNat Commun, Vol. 10, Page 4914-4914, Year 2019
Publish dateFeb 10, 2019 (structure data deposition date)
AuthorsLi, Y.J. / Cao, Y.L. / Feng, J.X. / Qi, Y. / Meng, S. / Yang, J.F. / Zhong, Y.T. / Kang, S. / Chen, X. / Lan, L. ...Li, Y.J. / Cao, Y.L. / Feng, J.X. / Qi, Y. / Meng, S. / Yang, J.F. / Zhong, Y.T. / Kang, S. / Chen, X. / Lan, L. / Luo, L. / Yu, B. / Chen, S. / Chan, D.C. / Hu, J. / Gao, S.
External linksNat Commun / PubMed:31664033
MethodsX-ray diffraction
Resolution1.997 - 2.806 Å
Structure data

PDB-6jfk:
GDP bound Mitofusin2 (MFN2)
Method: X-RAY DIFFRACTION / Resolution: 1.997 Å

PDB-6jfl:
Nucleotide-free Mitofusin2 (MFN2)
Method: X-RAY DIFFRACTION / Resolution: 2.806 Å

PDB-6jfm:
Mitofusin2 (MFN2)_T111D
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-CIT:
CITRIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
  • macaca mulatta (Rhesus monkey)
KeywordsMEMBRANE PROTEIN / mitochondriral fusion / GTPase activity / CMT2A

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