Entry Database : PDB / ID : 6jbu Structure visualization Downloads & linksTitle High resolution crystal structure of human FLRT3 LRR domain in complex with mouse CIRL3 Olfactomedin like domain ComponentsAdhesion G protein-coupled receptor L3 Leucine-rich repeat transmembrane protein FLRT3 DetailsKeywords CELL ADHESION / Membrane glycoprotein / ComplexFunction / homology Function and homology informationFunction Domain/homology Component
proepicardium cell migration involved in pericardium morphogenesis / locomotion involved in locomotory behavior / Rho-activating G protein-coupled receptor signaling pathway / cell adhesion mediator activity / excitatory synapse assembly / head development / growth cone membrane / synaptic membrane adhesion / cell-cell adhesion via plasma-membrane adhesion molecules / maintenance of postsynaptic specialization structure ... proepicardium cell migration involved in pericardium morphogenesis / locomotion involved in locomotory behavior / Rho-activating G protein-coupled receptor signaling pathway / cell adhesion mediator activity / excitatory synapse assembly / head development / growth cone membrane / synaptic membrane adhesion / cell-cell adhesion via plasma-membrane adhesion molecules / maintenance of postsynaptic specialization structure / fibroblast growth factor receptor binding / embryonic morphogenesis / Signaling by ROBO receptors / Downstream signaling of activated FGFR1 / chemorepellent activity / positive regulation of synapse assembly / neuron projection extension / fibroblast growth factor receptor signaling pathway / response to axon injury / axonal growth cone / synapse assembly / axon terminus / extracellular matrix / axon guidance / synaptic membrane / response to cocaine / molecular condensate scaffold activity / G protein-coupled receptor activity / synapse organization / Schaffer collateral - CA1 synapse / adenylate cyclase-activating G protein-coupled receptor signaling pathway / neuron migration / neuron projection development / cell-cell junction / cell junction / heart development / carbohydrate binding / protein-macromolecule adaptor activity / postsynaptic membrane / cell surface receptor signaling pathway / axon / focal adhesion / calcium ion binding / endoplasmic reticulum membrane / glutamatergic synapse / protein homodimerization activity / extracellular space / plasma membrane / cytosol Similarity search - Function : / GPCR, family 2, latrophilin, C-terminal / GPCR, family 2, latrophilin / Latrophilin Cytoplasmic C-terminal region / D-galactoside/L-rhamnose binding SUEL lectin domain superfamily / D-galactoside/L-rhamnose binding SUEL lectin domain / D-galactoside/L-rhamnose binding SUEL lectin domain / SUEL-type lectin domain profile. / GAIN domain, N-terminal / GPCR-Autoproteolysis INducing (GAIN) domain ... : / GPCR, family 2, latrophilin, C-terminal / GPCR, family 2, latrophilin / Latrophilin Cytoplasmic C-terminal region / D-galactoside/L-rhamnose binding SUEL lectin domain superfamily / D-galactoside/L-rhamnose binding SUEL lectin domain / D-galactoside/L-rhamnose binding SUEL lectin domain / SUEL-type lectin domain profile. / GAIN domain, N-terminal / GPCR-Autoproteolysis INducing (GAIN) domain / Olfactomedin-like domain / Olfactomedin-like domain / Olfactomedin-like domain profile. / Olfactomedin-like domains / GAIN domain superfamily / GPCR proteolysis site, GPS, motif / : / GPS motif / GAIN-B domain profile. / G-protein-coupled receptor proteolytic site domain / Leucine-rich repeat N-terminal domain / Leucine rich repeat N-terminal domain / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / Hormone receptor domain / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / Alpha-Beta Horseshoe / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Leucine-rich repeat domain superfamily / Immunoglobulin-like fold / Alpha Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.849 Å DetailsAuthors Liu, H. / Li, Z. / Xu, F. CitationJournal : To Be Published Title : High resolution crystal structure of human FLRT3 LRR domain in complex with mouse CIRL3 Olfactomedin like domainAuthors : Liu, H. / Li, Z. / Xu, F. History Deposition Jan 26, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jan 29, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Jul 29, 2020 Group : Data collection / Derived calculations / Structure summaryCategory : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_struct_conn_angle / struct_conn / struct_conn_type / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn_type.id Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 1.2 Nov 22, 2023 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accessionRevision 1.3 Nov 20, 2024 Group : Structure summary / Category : pdbx_entry_details / pdbx_modification_feature
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