登録情報 | データベース: PDB / ID: 6iq5 |
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タイトル | Crystal Structure of CYP1B1 and Inhibitor Having Azide Group |
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要素 | Cytochrome P450 1B1 |
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キーワード | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Cytochrome P450 / Inhibitor / CYP1B1 / azide / OXIDOREDUCTASE / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
trabecular meshwork development / cellular response to cortisol stimulus / response to indole-3-methanol / Defective CYP1B1 causes Glaucoma / endothelial cell-cell adhesion / benzene-containing compound metabolic process / membrane lipid catabolic process / hydroperoxy icosatetraenoate dehydratase / hydroperoxy icosatetraenoate dehydratase activity / ganglion development ...trabecular meshwork development / cellular response to cortisol stimulus / response to indole-3-methanol / Defective CYP1B1 causes Glaucoma / endothelial cell-cell adhesion / benzene-containing compound metabolic process / membrane lipid catabolic process / hydroperoxy icosatetraenoate dehydratase / hydroperoxy icosatetraenoate dehydratase activity / ganglion development / retinal blood vessel morphogenesis / Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) / response to follicle-stimulating hormone / omega-hydroxylase P450 pathway / response to 3-methylcholanthrene / toxin metabolic process / epoxygenase P450 pathway / blood vessel endothelial cell migration / arachidonic acid metabolic process / cellular response to toxic substance / DNA modification / estrogen 16-alpha-hydroxylase activity / retinal metabolic process / cellular response to progesterone stimulus / cellular response to luteinizing hormone stimulus / Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) / sterol metabolic process / negative regulation of cell adhesion mediated by integrin / response to arsenic-containing substance / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / collagen fibril organization / blood vessel morphogenesis / regulation of reactive oxygen species metabolic process / estrogen metabolic process / retinol metabolic process / unspecific monooxygenase / aromatase activity / intrinsic apoptotic signaling pathway in response to oxidative stress / adrenal gland development / positive regulation of DNA biosynthetic process / negative regulation of NF-kappaB transcription factor activity / response to dexamethasone / positive regulation of smooth muscle cell migration / steroid metabolic process / cellular response to organic cyclic compound / estrous cycle / positive regulation of vascular endothelial growth factor production / endothelial cell migration / Endogenous sterols / cellular response to cAMP / nitric oxide biosynthetic process / monooxygenase activity / xenobiotic metabolic process / negative regulation of cell migration / response to nutrient / positive regulation of translation / positive regulation of receptor signaling pathway via JAK-STAT / cellular response to hydrogen peroxide / positive regulation of angiogenesis / male gonad development / positive regulation of reactive oxygen species metabolic process / response to estradiol / cellular response to tumor necrosis factor / angiogenesis / cell adhesion / iron ion binding / positive regulation of apoptotic process / negative regulation of cell population proliferation / intracellular membrane-bounded organelle / heme binding / endoplasmic reticulum membrane / mitochondrion類似検索 - 分子機能 Cytochrome P450, E-class, group I / Cytochrome p450 / Cytochrome P450 / Cytochrome P450, conserved site / Cytochrome P450 cysteine heme-iron ligand signature. / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450 / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-AQ0 / PROTOPORPHYRIN IX CONTAINING FE / Cytochrome P450 1B1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 3.7 Å |
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データ登録者 | Kubo, M. / Yamamoto, K. / Itoh, T. |
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引用 | ジャーナル: Bioorg. Med. Chem. / 年: 2019 タイトル: Design and synthesis of selective CYP1B1 inhibitor via dearomatization of alpha-naphthoflavone. 著者: Kubo, M. / Yamamoto, K. / Itoh, T. |
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履歴 | 登録 | 2018年11月6日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2019年1月30日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年3月27日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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