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- PDB-6hw2: The Crystal Structure of CaV beta4c in complex with HP1gamma chro... -
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Open data
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Basic information
Entry | Database: PDB / ID: 6hw2 | |||||||||
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Title | The Crystal Structure of CaV beta4c in complex with HP1gamma chromo shadow domains | |||||||||
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![]() | TRANSPORT PROTEIN / Complex | |||||||||
Function / homology | ![]() voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels / chromatin lock complex / positive regulation of protein localization to nucleolus / Presynaptic depolarization and calcium channel opening / gamma-aminobutyric acid secretion / detection of light stimulus involved in visual perception / high voltage-gated calcium channel activity / cAMP metabolic process / histone methyltransferase binding / Peyer's patch development ...voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels / chromatin lock complex / positive regulation of protein localization to nucleolus / Presynaptic depolarization and calcium channel opening / gamma-aminobutyric acid secretion / detection of light stimulus involved in visual perception / high voltage-gated calcium channel activity / cAMP metabolic process / histone methyltransferase binding / Peyer's patch development / muscle cell development / condensed chromosome, centromeric region / gamma-aminobutyric acid signaling pathway / adult walking behavior / neuronal action potential propagation / nervous system process / nuclear inner membrane / voltage-gated calcium channel complex / neuromuscular junction development / regulation of synaptic vesicle exocytosis / negative regulation of G1/S transition of mitotic cell cycle / Transcriptional Regulation by E2F6 / site of DNA damage / chromosome, centromeric region / voltage-gated calcium channel activity / heterochromatin / pericentric heterochromatin / heterochromatin formation / spleen development / methylated histone binding / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / thymus development / cellular response to leukemia inhibitory factor / synaptic transmission, glutamatergic / transcription coregulator binding / regulation of membrane potential / RNA Polymerase I Promoter Escape / euchromatin / intracellular calcium ion homeostasis / spindle / RNA polymerase II transcription regulator complex / calcium ion transport / rhythmic process / presynapse / chromatin organization / nuclear envelope / T cell receptor signaling pathway / chemical synaptic transmission / chromosome, telomeric region / nuclear speck / chromatin remodeling / negative regulation of cell population proliferation / protein domain specific binding / negative regulation of DNA-templated transcription / glutamatergic synapse / DNA damage response / chromatin binding / chromatin / protein kinase binding / enzyme binding / negative regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / nucleus / plasma membrane Similarity search - Function | |||||||||
Biological species | ![]() ![]() ![]() | |||||||||
Method | ![]() ![]() ![]() | |||||||||
![]() | Tanner, N. / Tripathy, D.R. / Hirsch, J.A. | |||||||||
Funding support | ![]()
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![]() | ![]() Title: The Crystal Structure of CaV beta4c in complex with HP1gamma chromo shadow domains Authors: Tanner, N. / Tripathy, D.R. / Hirsch, J.A. | |||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 175.5 KB | Display | ![]() |
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PDB format | ![]() | 135.1 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 465.7 KB | Display | ![]() |
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Full document | ![]() | 467.5 KB | Display | |
Data in XML | ![]() | 14.4 KB | Display | |
Data in CIF | ![]() | 20.3 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 1vyvS S: Starting model for refinement |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
-Protein , 2 types, 3 molecules ABC
#1: Protein | Mass: 17531.834 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() Production host: ![]() ![]() References: UniProt: D4A055*PLUS |
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#2: Protein | Mass: 8468.519 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() Production host: ![]() ![]() References: UniProt: Q13185 |
-Non-polymers , 5 types, 213 molecules ![](data/chem/img/CA.gif)
![](data/chem/img/GOL.gif)
![](data/chem/img/BME.gif)
![](data/chem/img/ACT.gif)
![](data/chem/img/HOH.gif)
![](data/chem/img/GOL.gif)
![](data/chem/img/BME.gif)
![](data/chem/img/ACT.gif)
![](data/chem/img/HOH.gif)
#3: Chemical | ChemComp-CA / #4: Chemical | ChemComp-GOL / | #5: Chemical | ChemComp-BME / #6: Chemical | ChemComp-ACT / | #7: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.63 Å3/Da / Density % sol: 53.17 % |
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Crystal grow | Temperature: 292 K / Method: vapor diffusion, hanging drop / pH: 5 Details: 0.15 M NaCl, 12-14% PEG 3350 , pH 5.0, calcium acetate, VAPOR DIFFUSION, temperature 292K |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC QUANTUM 4 / Detector: CCD / Date: May 17, 2007 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 0.933 Å / Relative weight: 1 |
Reflection | Resolution: 1.941→33.12 Å / Num. obs: 26484 / % possible obs: 99.8 % / Redundancy: 5.2 % / Rmerge(I) obs: 0.047 / Net I/σ(I): 12.8 |
Reflection shell | Resolution: 1.941→2.01 Å / Rmerge(I) obs: 0.404 / Num. unique obs: 2518 |
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Processing
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Refinement | Method to determine structure: ![]() Starting model: 1VYV Resolution: 1.941→33.12 Å / Cross valid method: FREE R-VALUE
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Refinement step | Cycle: LAST / Resolution: 1.941→33.12 Å
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LS refinement shell | Resolution: 1.941→2.0104 Å
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