Entry Database : PDB / ID : 6hkq Structure visualization Downloads & linksTitle Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer) ComponentsPhospholipid hydroperoxide glutathione peroxidase Details Keywords OXIDOREDUCTASE / ANTI-OXIDATVE DEFENSE SYSTEM / Covalent inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
phospholipid-hydroperoxide glutathione peroxidase / phospholipid-hydroperoxide glutathione peroxidase activity / Synthesis of 15-eicosatetraenoic acid derivatives / Synthesis of 12-eicosatetraenoic acid derivatives / negative regulation of ferroptosis / selenium binding / Synthesis of 5-eicosatetraenoic acids / glutathione peroxidase / lipoxygenase pathway / Biosynthesis of aspirin-triggered D-series resolvins ... phospholipid-hydroperoxide glutathione peroxidase / phospholipid-hydroperoxide glutathione peroxidase activity / Synthesis of 15-eicosatetraenoic acid derivatives / Synthesis of 12-eicosatetraenoic acid derivatives / negative regulation of ferroptosis / selenium binding / Synthesis of 5-eicosatetraenoic acids / glutathione peroxidase / lipoxygenase pathway / Biosynthesis of aspirin-triggered D-series resolvins / Biosynthesis of E-series 18(R)-resolvins / arachidonic acid metabolic process / Biosynthesis of D-series resolvins / Biosynthesis of E-series 18(S)-resolvins / glutathione peroxidase activity / long-chain fatty acid biosynthetic process / protein polymerization / phospholipid metabolic process / response to estradiol / chromatin organization / nuclear envelope / cellular response to oxidative stress / spermatogenesis / response to oxidative stress / protein-containing complex / mitochondrion / extracellular exosome / identical protein binding / nucleus / cytosol Similarity search - Function Glutathione peroxidase active site / Glutathione peroxidases active site. / Glutathione peroxidase / Glutathione peroxidase conserved site / Glutathione peroxidase / Glutathione peroxidases signature 2. / Glutathione peroxidase profile. / Glutaredoxin / Glutaredoxin / Thioredoxin-like superfamily ... Glutathione peroxidase active site / Glutathione peroxidases active site. / Glutathione peroxidase / Glutathione peroxidase conserved site / Glutathione peroxidase / Glutathione peroxidases signature 2. / Glutathione peroxidase profile. / Glutaredoxin / Glutaredoxin / Thioredoxin-like superfamily / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 1.54 Å DetailsAuthors Hillig, R.C. / Moosmayer, D. / Hilpmann, A. / Hoffmann, L. / Schnirch, L. / Eaton, J.K. / Badock, V. / Gradl, S. CitationJournal : Acta Crystallogr D Struct Biol / Year : 2021Title : Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162.Authors : Moosmayer, D. / Hilpmann, A. / Hoffmann, J. / Schnirch, L. / Zimmermann, K. / Badock, V. / Furst, L. / Eaton, J.K. / Viswanathan, V.S. / Schreiber, S.L. / Gradl, S. / Hillig, R.C. History Deposition Sep 7, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 Apr 1, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Jun 16, 2021 Group : Database references / Category : citation / citation_authorItem : _citation.journal_abbrev / _citation.journal_id_CSD ... _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Dec 7, 2022 Group : Advisory / Database references ... Advisory / Database references / Derived calculations / Source and taxonomy Category : database_2 / entity_src_gen ... database_2 / entity_src_gen / pdbx_unobs_or_zero_occ_atoms / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity_src_gen.gene_src_common_name
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