Entry | Database: PDB / ID: 6g32 |
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Title | Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y |
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Components | Geranylgeranyl pyrophosphate synthase |
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Keywords | TRANSFERASE / geranylgeranyl diphosphate synthase / mevalonate pathway / prenyltransferase / GGPPS |
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Function / homology | Function and homology information
isoprenoid metabolic process / plastoquinone biosynthetic process / geranylgeranyl diphosphate biosynthetic process / geranylgeranyl diphosphate synthase / transferase complex / Transferases; Transferring alkyl or aryl groups, other than methyl groups / geranyl diphosphate biosynthetic process / dimethylallyltranstransferase / (2E,6E)-farnesyl diphosphate synthase / prenyltransferase activity ...isoprenoid metabolic process / plastoquinone biosynthetic process / geranylgeranyl diphosphate biosynthetic process / geranylgeranyl diphosphate synthase / transferase complex / Transferases; Transferring alkyl or aryl groups, other than methyl groups / geranyl diphosphate biosynthetic process / dimethylallyltranstransferase / (2E,6E)-farnesyl diphosphate synthase / prenyltransferase activity / Cholesterol biosynthesis / farnesyltranstransferase activity / ubiquinone biosynthetic process / isoprenoid biosynthetic process / farnesyl diphosphate biosynthetic process / dimethylallyltranstransferase activity / geranyltranstransferase activity / Activation of gene expression by SREBF (SREBP) / Z disc / perinuclear region of cytoplasm / mitochondrion / nucleoplasm / identical protein binding / metal ion binding / cytoplasm / cytosolSimilarity search - Function Polyprenyl synthases signature 1. / Polyprenyl synthases signature 2. / Polyprenyl synthetase, conserved site / Polyprenyl synthetase / Polyprenyl synthetase / Farnesyl Diphosphate Synthase / Farnesyl Diphosphate Synthase / Isoprenoid synthase domain superfamily / Orthogonal Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.281 Å |
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Authors | Lisnyansky, M. / Kapelushnik, N. / Ben-Bassat, A. / Marom, M. / Loewenstein, A. / Khananshvili, D. / Giladi, M. / Haitin, Y. |
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Funding support | Israel, 4items Organization | Grant number | Country |
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Other government | Israel Science Foundation (ISF) grant 1721/16 | Israel | Other government | Israel Science Foundation (ISF) grant 1775/12 | Israel | Other government | Israel Cancer Research Foundation (ICRF) grant 01214 | Israel | German Research Foundation | I-2425-418.13/2016 | Israel |
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Citation | Journal: Mol. Pharmacol. / Year: 2018 Title: Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures. Authors: Lisnyansky, M. / Kapelushnik, N. / Ben-Bassat, A. / Marom, M. / Loewenstein, A. / Khananshvili, D. / Giladi, M. / Haitin, Y. |
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History | Deposition | Mar 24, 2018 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Oct 17, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 24, 2018 | Group: Data collection / Database references / Category: citation Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Nov 7, 2018 | Group: Data collection / Database references / Category: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title |
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Revision 1.3 | Jan 17, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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