登録情報 | データベース: PDB / ID: 6g0g |
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タイトル | BRD4 (BD1) in complex with APSC-derived ligands (e.g. sulfasalazine) |
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要素 | Bromodomain-containing protein 4 BRD4 |
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キーワード | TRANSCRIPTION (転写 (生物学)) / BRD4 (BRD4) |
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機能・相同性 | 機能・相同性情報
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ...RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / 染色体 / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / クロマチンリモデリング / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / 核質 / 細胞核類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / ブロモドメイン / Bromodomain profile. / bromo domain / ブロモドメイン / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.478 Å |
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データ登録者 | Humbeck, L. / Pretzel, J. |
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資金援助 | ドイツ, 2件 組織 | 認可番号 | 国 |
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German Research Foundation | SPP 1736 | ドイツ | German Federal Ministry for Education and Research (BMBF) | BMBF Grant 1316053 | ドイツ |
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引用 | ジャーナル: Chemrxiv / 年: 2019 タイトル: Discovery of an Unexpected Similarity in Ligand Binding Between BRD4 and PPARgamma 著者: Humbeck, L. / Pretzel, J. / Spitzer, S. / Koch, O. |
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履歴 | 登録 | 2018年3月18日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2020年1月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月17日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_initial_refinement_model Item: _citation.journal_id_ISSN / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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