登録情報 | データベース: PDB / ID: 6fd0 |
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タイトル | Human KIBRA C2 domain mutant M734I S735A |
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要素 | Protein KIBRA |
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キーワード | LIPID BINDING PROTEIN / C2 domain / Kibra / phosphoinositide-binding / membrane interaction |
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機能・相同性 | 機能・相同性情報
regulation of intracellular transport / regulation of hippo signaling / negative regulation of organ growth / Signaling by Hippo / NOTCH3 Intracellular Domain Regulates Transcription / establishment of cell polarity / negative regulation of hippo signaling / kinase binding / ruffle membrane / cell migration ...regulation of intracellular transport / regulation of hippo signaling / negative regulation of organ growth / Signaling by Hippo / NOTCH3 Intracellular Domain Regulates Transcription / establishment of cell polarity / negative regulation of hippo signaling / kinase binding / ruffle membrane / cell migration / positive regulation of MAPK cascade / molecular adaptor activity / transcription coactivator activity / negative regulation of cell population proliferation / regulation of DNA-templated transcription / perinuclear region of cytoplasm / negative regulation of transcription by RNA polymerase II / protein-containing complex / nucleus / cytoplasm / cytosol類似検索 - 分子機能 WWC, C2 domain / C2 domain / C2 domain / WW domain / WW/rsp5/WWP domain signature. / C2 domain / C2 domain profile. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues ...WWC, C2 domain / C2 domain / C2 domain / WW domain / WW/rsp5/WWP domain signature. / C2 domain / C2 domain profile. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / C2 domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.64215847029 Å |
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データ登録者 | Crennell, S.J. / Posner, M.G. / Bagby, S. |
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資金援助 | 英国, 1件 組織 | 認可番号 | 国 |
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Biotechnology and Biological Sciences Research Council | BB/J008176/1 | 英国 |
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引用 | ジャーナル: J. Biol. Chem. / 年: 2018 タイトル: Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain. 著者: Posner, M.G. / Upadhyay, A. / Ishima, R. / Kalli, A.C. / Harris, G. / Kremerskothen, J. / Sansom, M.S.P. / Crennell, S.J. / Bagby, S. |
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履歴 | 登録 | 2017年12月21日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2018年5月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年6月27日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title |
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改定 1.2 | 2024年1月17日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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