- PDB-6fbk: Crystal structure of the human WNK2 CCT-like 1 domain in complex ... -
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基本情報
登録情報
データベース: PDB / ID: 6fbk
タイトル
Crystal structure of the human WNK2 CCT-like 1 domain in complex with a WNK1 RFXV peptide
要素
Serine/threonine-protein kinase WNK1
Serine/threonine-protein kinase WNK2
キーワード
PEPTIDE BINDING PROTEIN / WNK2 / CCT Domain / AI domain / RFXV motif binding
機能・相同性
機能・相同性情報
negative regulation of cell-cell adhesion mediated by integrin / lymphocyte migration into lymph node / chemokine (C-C motif) ligand 21 signaling pathway / positive regulation of termination of RNA polymerase II transcription / monoatomic cation homeostasis / negative regulation of pancreatic juice secretion / protein insertion into ER membrane by stop-transfer membrane-anchor sequence / positive regulation of sodium ion transmembrane transporter activity / positive regulation of mitotic cytokinesis / negative regulation of sodium ion transport ...negative regulation of cell-cell adhesion mediated by integrin / lymphocyte migration into lymph node / chemokine (C-C motif) ligand 21 signaling pathway / positive regulation of termination of RNA polymerase II transcription / monoatomic cation homeostasis / negative regulation of pancreatic juice secretion / protein insertion into ER membrane by stop-transfer membrane-anchor sequence / positive regulation of sodium ion transmembrane transporter activity / positive regulation of mitotic cytokinesis / negative regulation of sodium ion transport / monoatomic ion homeostasis / regulation of mRNA export from nucleus / positive regulation of potassium ion import across plasma membrane / regulation of sodium ion transmembrane transport / intracellular chloride ion homeostasis / negative regulation of heterotypic cell-cell adhesion / positive regulation of T cell chemotaxis / positive regulation of systemic arterial blood pressure / chloride channel inhibitor activity / non-membrane-bounded organelle assembly / potassium ion homeostasis / cellular response to chemokine / potassium channel inhibitor activity / negative regulation of leukocyte cell-cell adhesion / cellular hyperosmotic response / regulation of monoatomic cation transmembrane transport / cell volume homeostasis / negative regulation of protein localization to plasma membrane / negative regulation of GTPase activity / intracellular non-membrane-bounded organelle / protein kinase activator activity / sodium ion transmembrane transport / neuron development / phosphatase binding / monoatomic ion transport / regulation of sodium ion transport / negative regulation of protein ubiquitination / negative regulation of autophagy / molecular condensate scaffold activity / peptidyl-threonine phosphorylation / Stimuli-sensing channels / negative regulation of ERK1 and ERK2 cascade / mitotic spindle / positive regulation of angiogenesis / positive regulation of canonical Wnt signaling pathway / heart development / T cell receptor signaling pathway / peptidyl-serine phosphorylation / protein autophosphorylation / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / negative regulation of cell population proliferation / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / protein kinase binding / signal transduction / protein-containing complex / ATP binding / membrane / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能
Serine/threonine-protein kinase OSR1/WNK, CCT domain / Oxidative-stress-responsive kinase 1 C-terminal domain / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ubiquitin-like (UB roll) / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Roll / Protein kinase domain profile. ...Serine/threonine-protein kinase OSR1/WNK, CCT domain / Oxidative-stress-responsive kinase 1 C-terminal domain / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ubiquitin-like (UB roll) / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Roll / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Alpha Beta 類似検索 - ドメイン・相同性
Serine/threonine-proteinkinaseWNK2 / Antigen NY-CO-43 / Protein kinase lysine-deficient 2 / Protein kinase with no lysine 2 / ...Antigen NY-CO-43 / Protein kinase lysine-deficient 2 / Protein kinase with no lysine 2 / Serologically defined colon cancer antigen 43
Serine/threonine-proteinkinaseWNK1 / Erythrocyte 65 kDa protein / p65 / Kinase deficient protein / Protein kinase lysine-deficient 1 / ...Erythrocyte 65 kDa protein / p65 / Kinase deficient protein / Protein kinase lysine-deficient 1 / Protein kinase with no lysine 1 / hWNK1
分子量: 2610.046 Da / 分子数: 1 / 由来タイプ: 合成 / 由来: (合成) Homo sapiens (ヒト) 参照: UniProt: Q9H4A3, non-specific serine/threonine protein kinase
解像度: 1.743→33.973 Å / SU ML: 0.31 / 交差検証法: FREE R-VALUE / σ(F): 1.35 / 位相誤差: 50.6 詳細: Refinement R factors are higher than expected for resolution and diffraction images show diffuse spots between the indexed spots that were not able to be integrated. Nevertheless, the structure appears correct.