Entry Database : PDB / ID : 6.0E+95 Structure visualization Downloads & linksTitle Chimeric structure of Saccharomyces cerevisiae GCN4 leucine zipper fused to Staphylococcus aureus AgrC cytoplasmic histidine kinase module (dataset isotropically truncated by HKL2000) ComponentsStaphylococcus aureus AgrC histidine kinase module fused to Saccharomyces cerevisiae GCN4 leucine zipper Details Keywords SIGNALING PROTEIN / Protein histidine kinase / bacterial quorum sensing / coiled coil / Bergerat foldFunction / homology Function and homology informationFunction Domain/homology Component
protein localization to nuclear periphery / FCERI mediated MAPK activation / Activation of the AP-1 family of transcription factors / response to amino acid starvation / mediator complex binding / negative regulation of ribosomal protein gene transcription by RNA polymerase II / positive regulation of cellular response to amino acid starvation / nitrogen catabolite activation of transcription from RNA polymerase II promoter / Oxidative Stress Induced Senescence / TFIID-class transcription factor complex binding ... protein localization to nuclear periphery / FCERI mediated MAPK activation / Activation of the AP-1 family of transcription factors / response to amino acid starvation / mediator complex binding / negative regulation of ribosomal protein gene transcription by RNA polymerase II / positive regulation of cellular response to amino acid starvation / nitrogen catabolite activation of transcription from RNA polymerase II promoter / Oxidative Stress Induced Senescence / TFIID-class transcription factor complex binding / positive regulation of RNA polymerase II transcription preinitiation complex assembly / positive regulation of transcription initiation by RNA polymerase II / amino acid biosynthetic process / cellular response to nutrient levels / cellular response to amino acid starvation / RNA polymerase II transcription regulator complex / DNA-binding transcription activator activity, RNA polymerase II-specific / RNA polymerase II-specific DNA-binding transcription factor binding / transcription regulator complex / sequence-specific DNA binding / DNA-binding transcription factor activity, RNA polymerase II-specific / intracellular signal transduction / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / chromatin binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / identical protein binding / nucleus Similarity search - Function Sensor histidine kinase NatK, C-terminal domain / GHKL domain / : / Basic region leucine zipper / Basic-leucine zipper (bZIP) domain signature. / Basic-leucine zipper (bZIP) domain profile. / basic region leucin zipper / Basic-leucine zipper domain superfamily / Basic-leucine zipper domain / Histidine kinase/HSP90-like ATPase superfamily Similarity search - Domain/homologyBiological species Saccharomyces cerevisiae (brewer's yeast)Staphylococcus aureus (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 2.25 Å DetailsAuthors Xie, Q. / Jeffrey, P.D. / Muir, T.W. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) AI042783 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM095880 United States
CitationJournal : Cell Chem Biol / Year : 2019Title : Identification of a Molecular Latch that Regulates Staphylococcal Virulence.Authors : Xie, Q. / Zhao, A. / Jeffrey, P.D. / Kim, M.K. / Bassler, B.L. / Stone, H.A. / Novick, R.P. / Muir, T.W. History Deposition Jul 31, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 27, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Mar 6, 2019 Group : Data collection / Database referencesCategory : citation / pdbx_database_proc / pdbx_seq_map_depositor_infoItem : _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI ... _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _pdbx_seq_map_depositor_info.one_letter_code / _pdbx_seq_map_depositor_info.one_letter_code_mod Revision 1.2 May 1, 2019 Group : Data collection / Database references / Category : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.3 Dec 18, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Mar 13, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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