Entry | Database: PDB / ID: 6dik |
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Title | Crystal structure of Bothropstoxin I (BthTX-I) complexed to Chicoric acid |
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Components | Basic phospholipase A2 homolog bothropstoxin-1 |
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Keywords | TOXIN / Bothropd jararacussu / BthTX-I / Inhibitor / Chicoric Acid / Cichoric Acid / PLA2 |
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Function / homology | Function and homology information
calcium-dependent phospholipase A2 activity / arachidonic acid secretion / phospholipid metabolic process / lipid catabolic process / negative regulation of T cell proliferation / phospholipid binding / heparin binding / toxin activity / defense response to bacterium / calcium ion binding / extracellular regionSimilarity search - Function Phospholipase A2, aspartic acid active site / Phospholipase A2 aspartic acid active site. / Phospholipase A2 / Phospholipase A2, histidine active site / Phospholipase A2 histidine active site. / Phospholipase A2 / Phospholipase A2 domain / Phospholipase A2 / Phospholipase A2 / Phospholipase A2 domain ...Phospholipase A2, aspartic acid active site / Phospholipase A2 aspartic acid active site. / Phospholipase A2 / Phospholipase A2, histidine active site / Phospholipase A2 histidine active site. / Phospholipase A2 / Phospholipase A2 domain / Phospholipase A2 / Phospholipase A2 / Phospholipase A2 domain / Phospholipase A2 domain superfamily / Up-down Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Bothrops jararacussu (jararacussu) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 1.93 Å |
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Authors | Cardoso, F.F. / Salvador, G.H.M. / Borges, R.J. |
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Funding support | Brazil, 1items Organization | Grant number | Country |
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Sao Paulo Research Foundation (FAPESP) | 2012/07112-6 | Brazil |
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Citation | Journal: Biochim Biophys Acta Gen Subj / Year: 2018 Title: Structural basis of phospholipase A2-like myotoxin inhibition by chicoric acid, a novel potent inhibitor of ophidian toxins. Authors: Cardoso, F.F. / Borges, R.J. / Dreyer, T.R. / Salvador, G.H.M. / Cavalcante, W.L.G. / Pai, M.D. / Gallacci, M. / Fontes, M.R.M. |
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History | Deposition | May 23, 2018 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Oct 3, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 31, 2018 | Group: Data collection / Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name |
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Revision 1.2 | Jan 1, 2020 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.3 | Oct 11, 2023 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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