Entry | Database: PDB / ID: 4yz7 |
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Title | Crystal structure of Piratoxin I (PrTX-I) complexed to aristolochic acid |
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Components | Basic phospholipase A2 homolog piratoxin-1 |
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Keywords | TOXIN / phospholipase A2 / phospholipase A2-like / inhibitor |
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Function / homology | Function and homology information
calcium-dependent phospholipase A2 activity / arachidonate secretion / phospholipid metabolic process / lipid catabolic process / negative regulation of T cell proliferation / phospholipid binding / toxin activity / calcium ion binding / extracellular regionSimilarity search - Function Phospholipase A2, aspartic acid active site / Phospholipase A2 aspartic acid active site. / Phospholipase A2 / Phospholipase A2, histidine active site / Phospholipase A2 histidine active site. / Phospholipase A2 / Phospholipase A2 domain / Phospholipase A2 / Phospholipase A2 / Phospholipase A2 domain ...Phospholipase A2, aspartic acid active site / Phospholipase A2 aspartic acid active site. / Phospholipase A2 / Phospholipase A2, histidine active site / Phospholipase A2 histidine active site. / Phospholipase A2 / Phospholipase A2 domain / Phospholipase A2 / Phospholipase A2 / Phospholipase A2 domain / Phospholipase A2 domain superfamily / Up-down Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Bothrops pirajai (snake) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.9589 Å |
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Authors | Fernandes, C.A.H. / Fontes, M.R.M. |
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Funding support | Brazil, 2items Organization | Grant number | Country |
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Sao Paulo Research Foundation (FAPESP) | 2009/10905-5 | Brazil | Sao Paulo Research Foundation (FAPESP) | 2013/17864-8 | Brazil |
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Citation | Journal: Plos One / Year: 2015 Title: Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids. Authors: Fernandes, C.A. / Cardoso, F.F. / Cavalcante, W.G. / Soares, A.M. / Dal-Pai, M. / Gallacci, M. / Fontes, M.R. |
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History | Deposition | Mar 24, 2015 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Aug 5, 2015 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 1, 2017 | Group: Author supporting evidence / Derived calculations Category: pdbx_struct_assembly_auth_evidence / pdbx_struct_oper_list Item: _pdbx_struct_oper_list.symmetry_operation |
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Revision 1.2 | Apr 17, 2019 | Group: Author supporting evidence / Data collection / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.3 | Jan 1, 2020 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.4 | Sep 27, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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