Entry Database : PDB / ID : 6dgk Structure visualization Downloads & linksTitle Crystal Structure of the Non-Structural Protein 1 (NS1) effector domain W187A mutant from the A/Brevig Mission/1/1918 (H1N1) strain of Influenza A Virus ComponentsNon-structural protein 1 Details Keywords VIRAL PROTEIN / Influenza / NS1 / effector domain / W187AFunction / homology Function and homology informationFunction Domain/homology Component
symbiont-mediated suppression of host mRNA processing / symbiont-mediated suppression of host PKR/eIFalpha signaling / protein serine/threonine kinase inhibitor activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / host cell cytoplasm / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / virus-mediated perturbation of host defense response / host cell nucleus / RNA binding Similarity search - Function Influenza virus non-structural protein, effector domain / Influenza A virus NS1 protein / Influenza A virus NS1, effector domain-like superfamily / Influenza non-structural protein (NS1) / Influenza non-structural protein (NS1) / Nucleotidyltransferase; domain 5 / S15/NS1, RNA-binding / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Influenza A virusMethod X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.9 Å DetailsAuthors Kleinpeter, A.B. / Green, T.J. / Petit, C.M. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) 1R01AI116738 United States National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) 1R01AI134693 United States
CitationJournal : J. Biol. Chem. / Year : 2018Title : Structural analyses reveal the mechanism of inhibition of influenza virus NS1 by two antiviral compounds.Authors : Kleinpeter, A.B. / Jureka, A.S. / Falahat, S.M. / Green, T.J. / Petit, C.M. History Deposition May 17, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 15, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Oct 3, 2018 Group : Data collection / Database references / Category : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.2 Dec 18, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.3 Mar 13, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less