登録情報 | データベース: PDB / ID: 6cm4 |
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タイトル | Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone |
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要素 | D(2) dopamine receptor, endolysin chimera |
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キーワード | MEMBRANE PROTEIN / GPCR / D2 / dopamine receptor / antipsychotic / risperidone |
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機能・相同性 | 機能・相同性情報
regulation of locomotion involved in locomotory behavior / negative regulation of dopamine receptor signaling pathway / positive regulation of dopamine uptake involved in synaptic transmission / negative regulation of circadian sleep/wake cycle, sleep / acid secretion / positive regulation of glial cell-derived neurotrophic factor production / dopamine neurotransmitter receptor activity, coupled via Gi/Go / auditory behavior / nervous system process involved in regulation of systemic arterial blood pressure / regulation of synapse structural plasticity ...regulation of locomotion involved in locomotory behavior / negative regulation of dopamine receptor signaling pathway / positive regulation of dopamine uptake involved in synaptic transmission / negative regulation of circadian sleep/wake cycle, sleep / acid secretion / positive regulation of glial cell-derived neurotrophic factor production / dopamine neurotransmitter receptor activity, coupled via Gi/Go / auditory behavior / nervous system process involved in regulation of systemic arterial blood pressure / regulation of synapse structural plasticity / response to histamine / positive regulation of renal sodium excretion / adenohypophysis development / neuron-neuron synaptic transmission / hyaloid vascular plexus regression / cerebral cortex GABAergic interneuron migration / regulation of potassium ion transport / negative regulation of neuron migration / Dopamine receptors / adenylate cyclase-inhibiting dopamine receptor signaling pathway / negative regulation of cellular response to hypoxia / orbitofrontal cortex development / response to inactivity / dopamine binding / regulation of dopamine uptake involved in synaptic transmission / branching morphogenesis of a nerve / negative regulation of voltage-gated calcium channel activity / negative regulation of dopamine secretion / positive regulation of growth hormone secretion / heterotrimeric G-protein binding / behavioral response to ethanol / dopaminergic synapse / drinking behavior / peristalsis / G protein-coupled receptor complex / phospholipase C-activating dopamine receptor signaling pathway / grooming behavior / positive regulation of G protein-coupled receptor signaling pathway / positive regulation of urine volume / striatum development / negative regulation of adenylate cyclase activity / positive regulation of multicellular organism growth / negative regulation of synaptic transmission, glutamatergic / G protein-coupled receptor internalization / non-motile cilium / response to morphine / adult walking behavior / response to iron ion / ciliary membrane / regulation of synaptic transmission, GABAergic / dopamine uptake involved in synaptic transmission / arachidonic acid secretion / temperature homeostasis / pigmentation / postsynaptic modulation of chemical synaptic transmission / heterocyclic compound binding / dopamine metabolic process / positive regulation of neuroblast proliferation / negative regulation of cytosolic calcium ion concentration / regulation of dopamine secretion / positive regulation of cytokinesis / associative learning / positive regulation of receptor internalization / behavioral response to cocaine / endocytic vesicle / lateral plasma membrane / G-protein alpha-subunit binding / neuroblast proliferation / response to axon injury / response to light stimulus / GABA-ergic synapse / potassium channel regulator activity / sperm flagellum / negative regulation of protein secretion / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of insulin secretion / prepulse inhibition / long-term memory / axon terminus / adenylate cyclase-activating adrenergic receptor signaling pathway / regulation of sodium ion transport / release of sequestered calcium ion into cytosol / viral release from host cell by cytolysis / synapse assembly / response to amphetamine / presynaptic modulation of chemical synaptic transmission / negative regulation of blood pressure / negative regulation of innate immune response / excitatory postsynaptic potential / regulation of heart rate / peptidoglycan catabolic process / negative regulation of cell migration / axonogenesis / phosphatidylinositol 3-kinase/protein kinase B signal transduction / acrosomal vesicle / negative regulation of protein phosphorylation / response to cocaine / epithelial cell proliferation / positive regulation of long-term synaptic potentiation / locomotory behavior類似検索 - 分子機能 Dopamine D2 receptor / Dopamine receptor family / Endolysin T4 type / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like ...Dopamine D2 receptor / Dopamine receptor family / Endolysin T4 type / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Lysozyme-like domain superfamily類似検索 - ドメイン・相同性 Chem-8NU / OLEIC ACID / DI(HYDROXYETHYL)ETHER / Endolysin / D(2) dopamine receptor類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Enterobacteria phage T4 (ファージ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.867 Å |
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データ登録者 | Wang, S. / Che, T. / Levit, A. / Shoichet, B.K. / Wacker, D. / Roth, B.L. |
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資金援助 | 米国, 7件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Mental Health (NIH/NIMH) | RO1MH61887 | 米国 | National Institutes of Health/National Institute of Mental Health (NIH/NIMH) | U19MH82441 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM59957 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | P30CA016086 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | ACB-12002 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | AGM-12006 | 米国 | Department of Energy (DOE, United States) | DE-AC02-06CH11357 | 米国 |
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引用 | ジャーナル: Nature / 年: 2018 タイトル: Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone. 著者: Wang, S. / Che, T. / Levit, A. / Shoichet, B.K. / Wacker, D. / Roth, B.L. |
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履歴 | 登録 | 2018年3月2日 | 登録サイト: RCSB / 処理サイト: RCSB |
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置き換え | 2018年3月14日 | ID: 6C38 |
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改定 1.0 | 2018年3月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年3月21日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title |
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改定 1.2 | 2018年4月11日 | Group: Data collection / Database references / カテゴリ: struct_ref_seq / Item: _struct_ref_seq.pdbx_auth_seq_align_beg |
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改定 1.3 | 2019年2月20日 | Group: Author supporting evidence / Data collection / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2019年11月27日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.5 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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