Entry Database : PDB / ID : 6cm4 Structure visualization Downloads & linksTitle Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone ComponentsD(2) dopamine receptor, endolysin chimera Details Keywords MEMBRANE PROTEIN / GPCR / D2 / dopamine receptor / antipsychotic / risperidoneFunction / homology Function and homology informationFunction Domain/homology Component
regulation of locomotion involved in locomotory behavior / negative regulation of dopamine receptor signaling pathway / positive regulation of dopamine uptake involved in synaptic transmission / negative regulation of circadian sleep/wake cycle, sleep / acid secretion / positive regulation of glial cell-derived neurotrophic factor production / dopamine neurotransmitter receptor activity, coupled via Gi/Go / auditory behavior / nervous system process involved in regulation of systemic arterial blood pressure / regulation of synapse structural plasticity ... regulation of locomotion involved in locomotory behavior / negative regulation of dopamine receptor signaling pathway / positive regulation of dopamine uptake involved in synaptic transmission / negative regulation of circadian sleep/wake cycle, sleep / acid secretion / positive regulation of glial cell-derived neurotrophic factor production / dopamine neurotransmitter receptor activity, coupled via Gi/Go / auditory behavior / nervous system process involved in regulation of systemic arterial blood pressure / regulation of synapse structural plasticity / response to histamine / positive regulation of renal sodium excretion / neuron-neuron synaptic transmission / adenohypophysis development / cerebral cortex GABAergic interneuron migration / regulation of potassium ion transport / hyaloid vascular plexus regression / negative regulation of neuron migration / Dopamine receptors / adenylate cyclase-inhibiting dopamine receptor signaling pathway / negative regulation of cellular response to hypoxia / orbitofrontal cortex development / response to inactivity / regulation of dopamine uptake involved in synaptic transmission / branching morphogenesis of a nerve / negative regulation of voltage-gated calcium channel activity / dopamine binding / negative regulation of dopamine secretion / positive regulation of growth hormone secretion / heterotrimeric G-protein binding / behavioral response to ethanol / drinking behavior / peristalsis / G protein-coupled receptor complex / phospholipase C-activating dopamine receptor signaling pathway / dopaminergic synapse / grooming behavior / positive regulation of urine volume / positive regulation of G protein-coupled receptor signaling pathway / striatum development / negative regulation of adenylate cyclase activity / negative regulation of synaptic transmission, glutamatergic / positive regulation of multicellular organism growth / G protein-coupled receptor internalization / non-motile cilium / response to morphine / adult walking behavior / response to iron ion / ciliary membrane / regulation of synaptic transmission, GABAergic / arachidonate secretion / temperature homeostasis / pigmentation / dopamine uptake involved in synaptic transmission / postsynaptic modulation of chemical synaptic transmission / dopamine metabolic process / regulation of dopamine secretion / positive regulation of neuroblast proliferation / heterocyclic compound binding / negative regulation of cytosolic calcium ion concentration / positive regulation of cytokinesis / associative learning / positive regulation of receptor internalization / behavioral response to cocaine / endocytic vesicle / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / lateral plasma membrane / G-protein alpha-subunit binding / neuroblast proliferation / response to light stimulus / sperm flagellum / response to axon injury / potassium channel regulator activity / GABA-ergic synapse / negative regulation of protein secretion / negative regulation of insulin secretion / long-term memory / prepulse inhibition / adenylate cyclase-activating adrenergic receptor signaling pathway / regulation of sodium ion transport / axon terminus / release of sequestered calcium ion into cytosol / viral release from host cell by cytolysis / epithelial cell proliferation / synapse assembly / response to amphetamine / presynaptic modulation of chemical synaptic transmission / negative regulation of blood pressure / ionotropic glutamate receptor binding / negative regulation of innate immune response / regulation of heart rate / phosphatidylinositol 3-kinase/protein kinase B signal transduction / peptidoglycan catabolic process / axonogenesis / acrosomal vesicle / excitatory postsynaptic potential / negative regulation of protein phosphorylation / negative regulation of cell migration / response to cocaine / positive regulation of long-term synaptic potentiation Similarity search - Function Dopamine D2 receptor / Dopamine receptor family / Endolysin T4 type / : / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. ... Dopamine D2 receptor / Dopamine receptor family / Endolysin T4 type / : / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Lysozyme-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human) Enterobacteria phage T4 (virus)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.867 Å DetailsAuthors Wang, S. / Che, T. / Levit, A. / Shoichet, B.K. / Wacker, D. / Roth, B.L. Funding support United States, 7items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of Mental Health (NIH/NIMH) RO1MH61887 United States National Institutes of Health/National Institute of Mental Health (NIH/NIMH) U19MH82441 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM59957 United States National Institutes of Health/National Cancer Institute (NIH/NCI) P30CA016086 United States National Institutes of Health/National Cancer Institute (NIH/NCI) ACB-12002 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) AGM-12006 United States Department of Energy (DOE, United States) DE-AC02-06CH11357 United States
CitationJournal : Nature / Year : 2018Title : Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.Authors : Wang, S. / Che, T. / Levit, A. / Shoichet, B.K. / Wacker, D. / Roth, B.L. History Deposition Mar 2, 2018 Deposition site : RCSB / Processing site : RCSBSupersession Mar 14, 2018 ID : 6C38 Revision 1.0 Mar 14, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Mar 21, 2018 Group : Database references / Category : citationItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title Revision 1.2 Apr 11, 2018 Group : Data collection / Database references / Category : struct_ref_seq / Item : _struct_ref_seq.pdbx_auth_seq_align_begRevision 1.3 Feb 20, 2019 Group : Author supporting evidence / Data collection / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Nov 27, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.5 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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