登録情報 | データベース: PDB / ID: 6ckv |
---|
タイトル | Solution NMR structure of human BOK |
---|
要素 | Bcl-2-related ovarian killer protein |
---|
キーワード | APOPTOSIS |
---|
機能・相同性 | 機能・相同性情報
cellular component disassembly involved in execution phase of apoptosis / regulation of granulosa cell apoptotic process / regulation of chorionic trophoblast cell proliferation / positive regulation of PERK-mediated unfolded protein response / : / positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / cis-Golgi network membrane / positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / negative regulation of necroptotic process / negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ...cellular component disassembly involved in execution phase of apoptosis / regulation of granulosa cell apoptotic process / regulation of chorionic trophoblast cell proliferation / positive regulation of PERK-mediated unfolded protein response / : / positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / cis-Golgi network membrane / positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / negative regulation of necroptotic process / negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / nuclear outer membrane / negative regulation of mitochondrial depolarization / BH domain binding / positive regulation of execution phase of apoptosis / oligodendrocyte differentiation / intrinsic apoptotic signaling pathway by p53 class mediator / trans-Golgi network membrane / positive regulation of intrinsic apoptotic signaling pathway / extrinsic apoptotic signaling pathway in absence of ligand / regulation of cytosolic calcium ion concentration / protein complex oligomerization / release of cytochrome c from mitochondria / regulation of autophagy / mitochondrial membrane / : / intrinsic apoptotic signaling pathway in response to DNA damage / male gonad development / recycling endosome membrane / early endosome membrane / neuron apoptotic process / negative regulation of neuron apoptotic process / mitochondrial outer membrane / mitochondrial inner membrane / positive regulation of apoptotic process / protein heterodimerization activity / signaling receptor binding / ubiquitin protein ligase binding / endoplasmic reticulum membrane / protein-containing complex binding / apoptotic process / Golgi apparatus / endoplasmic reticulum / protein homodimerization activity / mitochondrion / membrane / nucleus / cytoplasm類似検索 - 分子機能 Bcl-2 family / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / BCL2-like apoptosis inhibitors family profile. / Apoptosis regulator proteins, Bcl-2 family / Bcl-2-like superfamily類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | 溶液NMR / torsion angle dynamics |
---|
データ登録者 | Grace, C.R. / Zheng, J. / Moldoveanu, T. |
---|
資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
---|
National Institutes of Health/National Cancer Institute (NIH/NCI) | P30CA021765-36 | 米国 |
|
---|
引用 | ジャーナル: Cell Rep / 年: 2018 タイトル: Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis. 著者: Zheng, J.H. / Grace, C.R. / Guibao, C.D. / McNamara, D.E. / Llambi, F. / Wang, Y.M. / Chen, T. / Moldoveanu, T. |
---|
履歴 | 登録 | 2018年3月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2018年5月9日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2018年5月23日 | Group: Data collection / Database references / Structure summary カテゴリ: audit_author / citation / citation_author Item: _audit_author.name / _citation.country ..._audit_author.name / _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation.year |
---|
改定 1.2 | 2018年7月4日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.page_last / _citation.pdbx_database_id_PubMed ..._citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name |
---|
改定 1.3 | 2019年12月4日 | Group: Author supporting evidence / Data collection カテゴリ: pdbx_audit_support / pdbx_nmr_software / pdbx_nmr_spectrometer Item: _pdbx_audit_support.country / _pdbx_audit_support.funding_organization ..._pdbx_audit_support.country / _pdbx_audit_support.funding_organization / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model |
---|
改定 1.4 | 2023年6月14日 | Group: Database references / Other / カテゴリ: database_2 / pdbx_database_status Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data |
---|
改定 1.5 | 2024年5月15日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
---|
|
---|