登録情報 データベース : PDB / ID : 6by8 構造の表示 ダウンロードとリンクタイトル Menin in complex with MI-1482 要素Menin 詳細 キーワード PROTEIN BINDING / inhibitor機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Y-form DNA binding / : / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of JNK cascade / T-helper 2 cell differentiation / MLL1/2 complex / R-SMAD binding / osteoblast development / histone methyltransferase complex / negative regulation of osteoblast differentiation ... Y-form DNA binding / : / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of JNK cascade / T-helper 2 cell differentiation / MLL1/2 complex / R-SMAD binding / osteoblast development / histone methyltransferase complex / negative regulation of osteoblast differentiation / Formation of WDR5-containing histone-modifying complexes / positive regulation of transforming growth factor beta receptor signaling pathway / cleavage furrow / MLL1 complex / negative regulation of cell cycle / RHO GTPases activate IQGAPs / response to UV / four-way junction DNA binding / transcription repressor complex / transcription initiation-coupled chromatin remodeling / negative regulation of protein phosphorylation / Deactivation of the beta-catenin transactivating complex / response to gamma radiation / phosphoprotein binding / Post-translational protein phosphorylation / Formation of the beta-catenin:TCF transactivating complex / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / negative regulation of DNA-binding transcription factor activity / nuclear matrix / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / MAPK cascade / double-stranded DNA binding / protein-macromolecule adaptor activity / chromosome, telomeric region / transcription cis-regulatory region binding / negative regulation of cell population proliferation / endoplasmic reticulum lumen / DNA repair / negative regulation of DNA-templated transcription / chromatin binding / DNA damage response / regulation of transcription by RNA polymerase II / chromatin / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / nucleus / cytoplasm / cytosol 類似検索 - 分子機能生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.9 Å 詳細データ登録者 Borkin, T. / Klossowski, S. / Pollock, J. / Linhares, B. / Cierpicki, T. / Grembecka, J. 引用ジャーナル : J.Med.Chem. / 年 : 2018タイトル : Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.著者 : Borkin, D. / Klossowski, S. / Pollock, J. / Miao, H. / Linhares, B.M. / Kempinska, K. / Jin, Z. / Purohit, T. / Wen, B. / He, M. / Sun, D. / Cierpicki, T. / Grembecka, J. 履歴 登録 2017年12月20日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2018年11月28日 Provider : repository / タイプ : Initial release改定 1.1 2019年6月12日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2023年10月4日 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
すべて表示 表示を減らす