Entry | Database: PDB / ID: 6boz |
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Title | Structure of human SETD8 in complex with covalent inhibitor MS4138 |
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Components | N-lysine methyltransferase KMT5A |
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Keywords | TRANSFERASE/TRANSFERASE inhibitor / protein-small molecule inhibitor complex / TRANSFERASE-TRANSFERASE inhibitor complex |
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Function / homology | Function and homology information
histone H4K20 monomethyltransferase activity / lysine N-methyltransferase activity / [histone H4]-lysine20 N-methyltransferase / histone H4K20 methyltransferase activity / histone H4 methyltransferase activity / polytene chromosome / peptidyl-lysine monomethylation / protein-lysine N-methyltransferase activity / mitotic chromosome condensation / regulation of DNA damage response, signal transduction by p53 class mediator ...histone H4K20 monomethyltransferase activity / lysine N-methyltransferase activity / [histone H4]-lysine20 N-methyltransferase / histone H4K20 methyltransferase activity / histone H4 methyltransferase activity / polytene chromosome / peptidyl-lysine monomethylation / protein-lysine N-methyltransferase activity / mitotic chromosome condensation / regulation of DNA damage response, signal transduction by p53 class mediator / histone methyltransferase activity / negative regulation of double-strand break repair via homologous recombination / Transferases; Transferring one-carbon groups; Methyltransferases / Condensation of Prophase Chromosomes / regulation of signal transduction by p53 class mediator / Regulation of TP53 Activity through Methylation / PKMTs methylate histone lysines / transcription corepressor activity / cell division / negative regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytosolSimilarity search - Function Class V SAM-dependent methyltransferases / : / : / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / Beta-clip-like / SET domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. ...Class V SAM-dependent methyltransferases / : / : / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / Beta-clip-like / SET domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / Beta Complex / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 2.4 Å |
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Authors | Babault, N. / Anqi, M. / Jin, J. |
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Funding support | United States, 3items Organization | Grant number | Country |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM122749 | United States | National Institutes of Health/National Cancer Institute (NIH/NCI) | R01CA218600 | United States | National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) | R01HD088626 | United States |
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Citation | Journal: Elife / Year: 2019 Title: The dynamic conformational landscape of the protein methyltransferase SETD8. Authors: Chen, S. / Wiewiora, R.P. / Meng, F. / Babault, N. / Ma, A. / Yu, W. / Qian, K. / Hu, H. / Zou, H. / Wang, J. / Fan, S. / Blum, G. / Pittella-Silva, F. / Beauchamp, K.A. / Tempel, W. / ...Authors: Chen, S. / Wiewiora, R.P. / Meng, F. / Babault, N. / Ma, A. / Yu, W. / Qian, K. / Hu, H. / Zou, H. / Wang, J. / Fan, S. / Blum, G. / Pittella-Silva, F. / Beauchamp, K.A. / Tempel, W. / Jiang, H. / Chen, K. / Skene, R.J. / Zheng, Y.G. / Brown, P.J. / Jin, J. / Luo, C. / Chodera, J.D. / Luo, M. |
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History | Deposition | Nov 21, 2017 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | May 1, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 29, 2019 | Group: Data collection / Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Dec 4, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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