Entry Database : PDB / ID : 6b91 Structure visualization Downloads & linksTitle Crystal structure of the N-terminal domain of human METTL16 ComponentsU6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase Details Keywords TRANSFERASE / Methyltransferase-like protein 16 / RNA methylation / N6-methyladenosineFunction / homology Function and homology informationFunction Domain/homology Component
snRNA (adenine-N6)-methylation / negative regulation of 3'-UTR-mediated mRNA stabilization / U6 snRNA m6A methyltransferase / U6 snRNA (adenine-(43)-N(6))-methyltransferase activity / 23S rRNA (adenine(1618)-N(6))-methyltransferase activity / U6 snRNA 3'-end binding / mRNA m6A methyltransferase / mRNA m(6)A methyltransferase activity / S-adenosylmethionine biosynthetic process / rRNA base methylation ... snRNA (adenine-N6)-methylation / negative regulation of 3'-UTR-mediated mRNA stabilization / U6 snRNA m6A methyltransferase / U6 snRNA (adenine-(43)-N(6))-methyltransferase activity / 23S rRNA (adenine(1618)-N(6))-methyltransferase activity / U6 snRNA 3'-end binding / mRNA m6A methyltransferase / mRNA m(6)A methyltransferase activity / S-adenosylmethionine biosynthetic process / rRNA base methylation / regulation of mRNA splicing, via spliceosome / post-transcriptional regulation of gene expression / mRNA destabilization / mRNA catabolic process / mRNA processing / RNA stem-loop binding / RNA binding / nucleus / cytoplasm Similarity search - Function Methyltransferase METTL16/PsiM / RNA methyltransferase / METTL16/RlmF family / S-adenosyl-L-methionine-dependent methyltransferase superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.94 Å DetailsAuthors Ruszkowska, A. / Ruszkowski, M. / Dauter, Z. / Brown, J.A. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R00GM111430 United States
CitationJournal : Sci Rep / Year : 2018Title : Structural insights into the RNA methyltransferase domain of METTL16.Authors : Ruszkowska, A. / Ruszkowski, M. / Dauter, Z. / Brown, J.A. History Deposition Oct 9, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 4, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Apr 11, 2018 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary Category : chem_comp / citation ... chem_comp / citation / entity / pdbx_entity_nonpoly Item : _chem_comp.name / _citation.page_first ... _chem_comp.name / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _entity.pdbx_description / _pdbx_entity_nonpoly.name Revision 1.2 Feb 20, 2019 Group : Author supporting evidence / Data collection ... Author supporting evidence / Data collection / Derived calculations / Structure summary Category : chem_comp / entity ... chem_comp / entity / pdbx_audit_support / pdbx_entity_nonpoly Item : _chem_comp.name / _entity.pdbx_description ... _chem_comp.name / _entity.pdbx_description / _pdbx_audit_support.funding_organization / _pdbx_entity_nonpoly.name Revision 1.3 Jan 1, 2020 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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