登録情報 | データベース: PDB / ID: 6b41 |
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タイトル | Menin bound to M-525 |
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要素 | Menin |
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キーワード | PROTEIN BINDING/INHIBITOR / Covalent Inhibitor / MEN1 syndrome / leukemia / PROTEIN BINDING-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
Y-form DNA binding / : / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of JNK cascade / T-helper 2 cell differentiation / MLL1/2 complex / osteoblast development / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / positive regulation of transforming growth factor beta receptor signaling pathway ...Y-form DNA binding / : / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of JNK cascade / T-helper 2 cell differentiation / MLL1/2 complex / osteoblast development / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / positive regulation of transforming growth factor beta receptor signaling pathway / R-SMAD binding / cleavage furrow / MLL1 complex / negative regulation of cell cycle / RHO GTPases activate IQGAPs / negative regulation of osteoblast differentiation / response to UV / four-way junction DNA binding / transcription repressor complex / transcription initiation-coupled chromatin remodeling / negative regulation of protein phosphorylation / Deactivation of the beta-catenin transactivating complex / response to gamma radiation / phosphoprotein binding / Post-translational protein phosphorylation / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / Formation of the beta-catenin:TCF transactivating complex / negative regulation of DNA-binding transcription factor activity / nuclear matrix / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / MAPK cascade / protein-macromolecule adaptor activity / double-stranded DNA binding / chromosome, telomeric region / transcription cis-regulatory region binding / negative regulation of cell population proliferation / endoplasmic reticulum lumen / DNA repair / negative regulation of DNA-templated transcription / DNA damage response / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / nucleus / cytoplasm / cytosol類似検索 - 分子機能 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.61 Å |
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データ登録者 | Stuckey, J.A. |
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引用 | ジャーナル: Angew. Chem. Int. Ed. Engl. / 年: 2018 タイトル: Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. 著者: Xu, S. / Aguilar, A. / Xu, T. / Zheng, K. / Huang, L. / Stuckey, J. / Chinnaswamy, K. / Bernard, D. / Fernandez-Salas, E. / Liu, L. / Wang, M. / McEachern, D. / Przybranowski, S. / Foster, C. / Wang, S. |
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履歴 | 登録 | 2017年9月25日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年1月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年2月14日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year |
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改定 1.2 | 2023年10月4日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_special_symmetry Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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