Entry Database : PDB / ID : 6apd Structure visualization Downloads & linksTitle Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 ComponentsAM22 Fab Heavy Chain,IGH@ protein AM22 Fab Light Chain,Uncharacterized protein Fusion glycoprotein F0,Envelope glycoprotein IGL@ protein Immunoglobulin heavy variable 3-21,Immunoglobulin gamma-1 heavy chain DetailsKeywords IMMUNE SYSTEM / viral glycoprotein / immunoglobulin / infant / complexFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of syncytium formation by virus / Translation of respiratory syncytial virus mRNAs / positive regulation of B cell activation / phagocytosis, recognition / phagocytosis, engulfment / RSV-host interactions / Maturation of hRSV A proteins / Assembly and release of respiratory syncytial virus (RSV) virions / host cell Golgi membrane / Respiratory syncytial virus (RSV) attachment and entry ... positive regulation of syncytium formation by virus / Translation of respiratory syncytial virus mRNAs / positive regulation of B cell activation / phagocytosis, recognition / phagocytosis, engulfment / RSV-host interactions / Maturation of hRSV A proteins / Assembly and release of respiratory syncytial virus (RSV) virions / host cell Golgi membrane / Respiratory syncytial virus (RSV) attachment and entry / immunoglobulin complex, circulating / immunoglobulin receptor binding / complement activation, classical pathway / antigen binding / B cell receptor signaling pathway / antibacterial humoral response / entry receptor-mediated virion attachment to host cell / blood microparticle / defense response to bacterium / symbiont entry into host cell / immune response / fusion of virus membrane with host plasma membrane / external side of plasma membrane / innate immune response / viral envelope / host cell plasma membrane / virion membrane / extracellular space / extracellular exosome / identical protein binding / metal ion binding / plasma membrane Similarity search - Function Precursor fusion glycoprotein F0, Paramyxoviridae / Fusion glycoprotein F0 / Fibritin C-terminal / Fibritin C-terminal region / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin subtype ... Precursor fusion glycoprotein F0, Paramyxoviridae / Fusion glycoprotein F0 / Fibritin C-terminal / Fibritin C-terminal region / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold Similarity search - Domain/homology Immunoglobulin heavy variable 3-21 / Fusion glycoprotein F0 / Envelope glycoprotein / Fusion glycoprotein F0 / Immunoglobulin gamma-1 heavy chain / IGL@ protein / IGH@ protein / Ig-like domain-containing protein Similarity search - ComponentBiological species Respiratory syncytial virus Human immunodeficiency virus 1Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 4.1 Å DetailsAuthors Wrapp, D. / McLellan, J.S. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) T32GM008704 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) P41GM103393 United States
CitationJournal : Immunity / Year : 2018Title : Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.Authors : Goodwin, E. / Gilman, M.S.A. / Wrapp, D. / Chen, M. / Ngwuta, J.O. / Moin, S.M. / Bai, P. / Sivasubramanian, A. / Connor, R.I. / Wright, P.F. / Graham, B.S. / McLellan, J.S. / Walker, L.M. History Deposition Aug 17, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 21, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Jan 1, 2020 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization
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