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TitleInfants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.
Journal, issue, pagesImmunity, Vol. 48, Page 339-349.e5, Year 2018
Publish dateAug 17, 2017 (structure data deposition date)
AuthorsGoodwin, E. / Gilman, M.S.A. / Wrapp, D. / Chen, M. / Ngwuta, J.O. / Moin, S.M. / Bai, P. / Sivasubramanian, A. / Connor, R.I. / Wright, P.F. ...Goodwin, E. / Gilman, M.S.A. / Wrapp, D. / Chen, M. / Ngwuta, J.O. / Moin, S.M. / Bai, P. / Sivasubramanian, A. / Connor, R.I. / Wright, P.F. / Graham, B.S. / McLellan, J.S. / Walker, L.M.
External linksImmunity / PubMed:29396163
MethodsX-ray diffraction
Resolution1.7 - 4.1 Å
Structure data

PDB-6apb:
Crystal Structure of Non-Neutralizing Infant Antibody ADI-14359 in Complex with Postfusion RSV F Glycoprotein
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-6apc:
Crystal Structure of Infant Antibody ADI-19425
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-6apd:
Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425
Method: X-RAY DIFFRACTION / Resolution: 4.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • human respiratory syncytial virus
  • homo sapiens (human)
  • respiratory syncytial virus
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / viral fusion glycoprotein / immunoglobulin / respiratory syncytial virus / viral glycoprotein / infant / complex

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