登録情報 | データベース: PDB / ID: 6ael |
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タイトル | Crystal structure of ENPP1 in complex with 3'3'-cGAMP |
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要素 | Ectonucleotide pyrophosphatase/phosphodiesterase 1, isoform CRA_d |
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キーワード | IMMUNOSUPPRESSANT / Enzyme / Phoshodiesterase / cGAMP / cGAS-STING / cyclic GMP-AMP |
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機能・相同性 | 機能・相同性情報
articular cartilage development / microglial cell migration / Vitamin B2 (riboflavin) metabolism / response to platelet-derived growth factor / ligamentous ossification / response to vitamin B6 / cellular response to sodium phosphate / GTP diphosphatase activity / cyclic-GMP-AMP hydrolase activity / negative regulation of hh target transcription factor activity ...articular cartilage development / microglial cell migration / Vitamin B2 (riboflavin) metabolism / response to platelet-derived growth factor / ligamentous ossification / response to vitamin B6 / cellular response to sodium phosphate / GTP diphosphatase activity / cyclic-GMP-AMP hydrolase activity / negative regulation of hh target transcription factor activity / organic phosphonate metabolic process / post-embryonic forelimb morphogenesis / UTP diphosphatase activity / tooth mineralization / inorganic diphosphate transport / hematopoietic stem cell migration to bone marrow / leukocyte activation involved in inflammatory response / phosphodiesterase I / bone growth / biomineral tissue development / sensory perception of temperature stimulus / dinucleotide phosphatase activity / coenzyme A diphosphatase activity / basal dendrite / coenzyme A catabolic process / pyrophosphatase activity / vascular associated smooth muscle cell migration / nucleotide diphosphatase / nucleoside triphosphate catabolic process / inhibition of non-skeletal tissue mineralization / response to Gram-positive bacterium / magnesium ion homeostasis / diphosphate metabolic process / endochondral bone morphogenesis / bone trabecula formation / vitamin D3 metabolic process / cementum mineralization / central nervous system myelination / vascular associated smooth muscle cell proliferation / nucleoside triphosphate diphosphatase activity / bone mineralization involved in bone maturation / mucus secretion / response to sodium phosphate / ATP diphosphatase activity / phosphate ion homeostasis / negative regulation of bone mineralization / sensory perception of mechanical stimulus / plasma cell differentiation / B-1 B cell homeostasis / phosphodiesterase I activity / artery development / scavenger receptor activity / microglia differentiation / collagen-activated signaling pathway / cellular homeostasis / apoptotic process involved in development / endochondral ossification / apical dendrite / bone remodeling / phosphoric diester hydrolase activity / regulation of bone mineralization / hormone metabolic process / inflammatory response to antigenic stimulus / negative regulation of ossification / adult walking behavior / cartilage development / aorta development / middle ear morphogenesis / oligodendrocyte apoptotic process / odontogenesis / axon regeneration / fat pad development / skin development / smoothened signaling pathway / polysaccharide binding / response to ATP / muscle cell cellular homeostasis / spinal cord development / negative regulation of fat cell differentiation / bone mineralization / fat cell differentiation / defense response to protozoan / glucose import / phosphatase activity / response to dietary excess / response to magnesium ion / macrophage differentiation / T cell differentiation / : / 3',5'-cyclic-AMP phosphodiesterase activity / fibroblast growth factor receptor signaling pathway / calcium ion homeostasis / vasculogenesis / adipose tissue development / ATP metabolic process / bone resorption / mitochondrion organization / adult locomotory behavior / ossification / osteoclast differentiation類似検索 - 分子機能 Somatomedin B domain, chordata / Somatomedin B -like domains / Somatomedin B domain / Somatomedin B-like domain superfamily / Somatomedin B domain / Somatomedin B domain (SMB) signature. / Somatomedin B (SMB) domain profile. / Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase / Type I phosphodiesterase / nucleotide pyrophosphatase / Extracellular Endonuclease, subunit A ...Somatomedin B domain, chordata / Somatomedin B -like domains / Somatomedin B domain / Somatomedin B-like domain superfamily / Somatomedin B domain / Somatomedin B domain (SMB) signature. / Somatomedin B (SMB) domain profile. / Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase / Type I phosphodiesterase / nucleotide pyrophosphatase / Extracellular Endonuclease, subunit A / DNA/RNA non-specific endonuclease / DNA/RNA non-specific endonuclease / DNA/RNA non-specific endonuclease / DNA/RNA non-specific endonuclease / DNA/RNA non-specific endonuclease superfamily / His-Me finger superfamily / Alkaline-phosphatase-like, core domain superfamily類似検索 - ドメイン・相同性 Chem-4BW / Ectonucleotide pyrophosphatase/phosphodiesterase 1 / Ectonucleotide pyrophosphatase/phosphodiesterase family member 1類似検索 - 構成要素 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å |
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データ登録者 | Kato, K. / Nishimasu, H. / Hirano, S. / Hirano, H. / Ishitani, R. / Nureki, O. |
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引用 | ジャーナル: Nat Commun / 年: 2018 タイトル: Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. 著者: Kato, K. / Nishimasu, H. / Oikawa, D. / Hirano, S. / Hirano, H. / Kasuya, G. / Ishitani, R. / Tokunaga, F. / Nureki, O. |
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履歴 | 登録 | 2018年8月5日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2019年3月6日 | Provider: repository / タイプ: Initial release |
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改定 2.0 | 2020年7月29日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / struct_asym / struct_conn / struct_conn_type / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.pdbx_synonyms / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn_type.id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2023年11月22日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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