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Structure paper

TitleStructural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
Journal, issue, pagesNat Commun, Vol. 9, Page 4424-4424, Year 2018
Publish dateAug 5, 2018 (structure data deposition date)
AuthorsKato, K. / Nishimasu, H. / Oikawa, D. / Hirano, S. / Hirano, H. / Kasuya, G. / Ishitani, R. / Tokunaga, F. / Nureki, O.
External linksNat Commun / PubMed:30356045
MethodsX-ray diffraction
Resolution1.8 - 1.9 Å
Structure data

PDB-6aek:
Crystal structure of ENPP1 in complex with pApG
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6ael:
Crystal structure of ENPP1 in complex with 3'3'-cGAMP
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-5GP:
GUANOSINE-5'-MONOPHOSPHATE

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-4BW:
2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one

Source
  • mus musculus (house mouse)
KeywordsIMMUNOSUPPRESSANT / Enzyme / Phoshodiesterase / cGAMP / cGAS-STING / cyclic GMP-AMP

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