登録情報 | データベース: PDB / ID: 5zkb |
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タイトル | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with AF-DX 384 |
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要素 | Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2 |
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キーワード | MEMBRANE PROTEIN/INHIBITOR / GPCR crystallography / rationally thermostabilized mutant / MEMBRANE PROTEIN-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
Muscarinic acetylcholine receptors / symmetric synapse / phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway / G protein-coupled acetylcholine receptor activity / cholinergic synapse / regulation of smooth muscle contraction / adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway / G protein-coupled serotonin receptor activity / arrestin family protein binding / regulation of heart contraction ...Muscarinic acetylcholine receptors / symmetric synapse / phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway / G protein-coupled acetylcholine receptor activity / cholinergic synapse / regulation of smooth muscle contraction / adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway / G protein-coupled serotonin receptor activity / arrestin family protein binding / regulation of heart contraction / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / asymmetric synapse / axon terminus / presynaptic modulation of chemical synaptic transmission / clathrin-coated endocytic vesicle membrane / response to virus / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / G protein-coupled acetylcholine receptor signaling pathway / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / nervous system development / presynaptic membrane / G alpha (i) signalling events / chemical synaptic transmission / postsynaptic membrane / G protein-coupled receptor signaling pathway / neuronal cell body / glutamatergic synapse / synapse / dendrite / membrane / plasma membrane類似検索 - 分子機能 Muscarinic acetylcholine receptor M2 / Muscarinic acetylcholine receptor family / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family)類似検索 - ドメイン・相同性 Chem-82F / Muscarinic acetylcholine receptor M2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.95 Å |
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データ登録者 | Suno, R. / Maeda, S. / Yasuda, S. / Yamashita, K. / Hirata, K. / Horita, S. / Tawaramoto, M.S. / Tsujimoto, H. / Murata, T. / Kinoshita, M. ...Suno, R. / Maeda, S. / Yasuda, S. / Yamashita, K. / Hirata, K. / Horita, S. / Tawaramoto, M.S. / Tsujimoto, H. / Murata, T. / Kinoshita, M. / Yamamoto, M. / Kobilka, B.K. / Iwata, S. / Kobayashi, T. |
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資金援助 | 日本, 米国, 6件 組織 | 認可番号 | 国 |
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Japan Science and Technology | The Research Acceleration Program | 日本 | Ministry of Education, Culture, Sports, Science and Technology (Japan) | The Platform Project for Supporting Drug Discovery and Life Science Research | 日本 | Japan Society for the Promotion of Science | International Collaboration in Chemistry | 日本 | Japan Agency for Medical Research and Development (AMED) | The Platform Project for Supporting Drug Discovery and Life Science Research | 日本 | Japan Society for the Promotion of Science | 15K08268, 15H06862 | 日本 | National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | NIH R01-GM097261 | 米国 |
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引用 | ジャーナル: Nat. Chem. Biol. / 年: 2018 タイトル: Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor 著者: Suno, R. / Lee, S. / Maeda, S. / Yasuda, S. / Yamashita, K. / Hirata, K. / Horita, S. / Tawaramoto, M.S. / Tsujimoto, H. / Murata, T. / Kinoshita, M. / Yamamoto, M. / Kobilka, B.K. / Vaidehi, ...著者: Suno, R. / Lee, S. / Maeda, S. / Yasuda, S. / Yamashita, K. / Hirata, K. / Horita, S. / Tawaramoto, M.S. / Tsujimoto, H. / Murata, T. / Kinoshita, M. / Yamamoto, M. / Kobilka, B.K. / Vaidehi, N. / Iwata, S. / Kobayashi, T. |
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履歴 | 登録 | 2018年3月23日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2018年11月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年11月28日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_abbrev / _citation.journal_volume ..._citation.journal_abbrev / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID |
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改定 1.2 | 2022年3月23日 | Group: Author supporting evidence / Database references / カテゴリ: database_2 / pdbx_audit_support Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_audit_support.funding_organization |
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