- PDB-5yzb: Crystal Structure of Human CRMP-2 with S522D-T509D-T514D-S518D mu... -
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Basic information
Entry
Database: PDB / ID: 5yzb
Title
Crystal Structure of Human CRMP-2 with S522D-T509D-T514D-S518D mutations crystallized with GSK3b
Components
Dihydropyrimidinase-related protein 2
Keywords
CYTOSOLIC PROTEIN / developmental protein / phosphoprotein / microtubule associated proteins / neurogenesis / dihydropyrimidase-related protein / collapsin response mediator protein / protein binding
Function / homology
Function and homology information
dihydropyrimidinase activity / hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides / CRMPs in Sema3A signaling / nucleobase-containing compound metabolic process / Recycling pathway of L1 / cytoskeleton organization / endocytosis / nervous system development / cell differentiation / cytoskeleton ...dihydropyrimidinase activity / hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides / CRMPs in Sema3A signaling / nucleobase-containing compound metabolic process / Recycling pathway of L1 / cytoskeleton organization / endocytosis / nervous system development / cell differentiation / cytoskeleton / signal transduction / extracellular exosome / identical protein binding / plasma membrane / cytosol Similarity search - Function
Mass: 57467.832 Da / Num. of mol.: 1 / Mutation: T509D/T514D/S518D/S522D Source method: isolated from a genetically manipulated source Details: CRMP2-4D was crystallized with GSK3B, however, the electron density corresponding to GSK-3B was not observed Source: (gene. exp.) Homo sapiens (human) / Gene: DPYSL2, CRMP2, ULIP2 / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21(DE3) / References: UniProt: Q16555
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