登録情報 | データベース: PDB / ID: 5yz9 |
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タイトル | zinc finger domain of METTL3-METTL14 N6-methyladenosine methyltransferase |
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要素 | N6-adenosine-methyltransferase catalytic subunit |
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キーワード | RNA BINDING PROTEIN / rna binding / zinc finger / N6-methyladenosine methyltransferase |
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機能・相同性 | 機能・相同性情報
mRNA m6A methyltransferase / mRNA m(6)A methyltransferase activity / RNA N6-methyladenosine methyltransferase complex / positive regulation of cap-independent translational initiation / RNA methylation / endothelial to hematopoietic transition / regulation of meiotic cell cycle / RNA methyltransferase activity / primary miRNA processing / forebrain radial glial cell differentiation ...mRNA m6A methyltransferase / mRNA m(6)A methyltransferase activity / RNA N6-methyladenosine methyltransferase complex / positive regulation of cap-independent translational initiation / RNA methylation / endothelial to hematopoietic transition / regulation of meiotic cell cycle / RNA methyltransferase activity / primary miRNA processing / forebrain radial glial cell differentiation / dosage compensation by inactivation of X chromosome / oxidoreductase complex / S-adenosyl-L-methionine binding / gliogenesis / mRNA modification / regulation of hematopoietic stem cell differentiation / regulation of T cell differentiation / negative regulation of type I interferon-mediated signaling pathway / oogenesis / stem cell population maintenance / mRNA destabilization / Processing of Capped Intron-Containing Pre-mRNA / negative regulation of Notch signaling pathway / positive regulation of translation / mRNA splicing, via spliceosome / circadian rhythm / mRNA processing / cellular response to UV / spermatogenesis / nuclear speck / nuclear body / protein heterodimerization activity / innate immune response / mRNA binding / DNA damage response / Golgi apparatus / nucleoplasm / nucleus / cytosol類似検索 - 分子機能 N6-adenosine-methyltransferase MT-A70-like / mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) family profile. / MT-A70-like / MT-A70 / MT-A70-like family profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily類似検索 - ドメイン・相同性 N(6)-adenosine-methyltransferase catalytic subunit METTL3類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / 溶液散乱 / simulated annealing |
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データ登録者 | Dong, X. / Tang, C. / Gong, Z. / Yin, P. / Huang, J.B. |
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資金援助 | 中国, 6件 組織 | 認可番号 | 国 |
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National Key R&D Program of China | 2016YFA0501200 | 中国 | National Natural Science Foundation of China | 2015CB910900 | 中国 | National Natural Science Foundation of China | 31770799 | 中国 | National Natural Science Foundation of China | 81573400 | 中国 | National Natural Science Foundation of China | 31400644 | 中国 | National Natural Science Foundation of China | 31400735 | 中国 |
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引用 | ジャーナル: Protein Cell / 年: 2019 タイトル: Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. 著者: Huang, J. / Dong, X. / Gong, Z. / Qin, L.Y. / Yang, S. / Zhu, Y.L. / Wang, X. / Zhang, D. / Zou, T. / Yin, P. / Tang, C. |
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履歴 | 登録 | 2017年12月13日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2018年3月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年3月27日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation.year |
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改定 1.2 | 2024年5月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_spectrometer Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_spectrometer.model |
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