登録情報 | データベース: PDB / ID: 5yso |
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タイトル | Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434 |
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要素 | Estrogen-related receptor gamma |
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キーワード | TRANSCRIPTION / Sodium iodide symporter (NIS) / Anaplastic thyroid cancer / Estrogen-related receptor gamma / Radioiodine therapy |
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機能・相同性 | 機能・相同性情報
AF-2 domain binding / nuclear steroid receptor activity / retinoic acid receptor signaling pathway / estrogen response element binding / nuclear receptor-mediated steroid hormone signaling pathway / steroid binding / Nuclear Receptor transcription pathway / nuclear receptor activity / sequence-specific double-stranded DNA binding / positive regulation of cold-induced thermogenesis ...AF-2 domain binding / nuclear steroid receptor activity / retinoic acid receptor signaling pathway / estrogen response element binding / nuclear receptor-mediated steroid hormone signaling pathway / steroid binding / Nuclear Receptor transcription pathway / nuclear receptor activity / sequence-specific double-stranded DNA binding / positive regulation of cold-induced thermogenesis / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor activity, RNA polymerase II-specific / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / identical protein binding類似検索 - 分子機能 Oestrogen-related receptor / Retinoic acid receptor / Estrogen receptor/oestrogen-related receptor / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) ...Oestrogen-related receptor / Retinoic acid receptor / Estrogen receptor/oestrogen-related receptor / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.501 Å |
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データ登録者 | Cho, S.J. / Chin, J.W. / Yoon, H.S. / Jeon, Y.H. / Bae, J.H. / Song, J.Y. |
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資金援助 | 韓国, 1件 組織 | 認可番号 | 国 |
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the korea health industry development institute | HI16C1501 | 韓国 |
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引用 | ジャーナル: Clin.Cancer Res. / 年: 2019 タイトル: A Novel Orally Active Inverse Agonist of Estrogen-related Receptor Gamma (ERR gamma ), DN200434, A Booster of NIS in Anaplastic Thyroid Cancer. 著者: Singh, T.D. / Song, J. / Kim, J. / Chin, J. / Ji, H.D. / Lee, J.E. / Lee, S.B. / Yoon, H. / Yu, J.H. / Kim, S.K. / Yoon, G.S. / Hwang, H. / Lee, H.W. / Oh, J.M. / Lee, S.W. / Lee, J. / Choi, ...著者: Singh, T.D. / Song, J. / Kim, J. / Chin, J. / Ji, H.D. / Lee, J.E. / Lee, S.B. / Yoon, H. / Yu, J.H. / Kim, S.K. / Yoon, G.S. / Hwang, H. / Lee, H.W. / Oh, J.M. / Lee, S.W. / Lee, J. / Choi, H.S. / Na, S.Y. / Choi, W.I. / Park, Y.J. / Song, Y.S. / Kim, Y.A. / Lee, I.K. / Cho, S.J. / Jeon, Y.H. |
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履歴 | 登録 | 2017年11月14日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2018年12月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年5月1日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2019年8月28日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_abbrev / _citation.journal_volume ..._citation.journal_abbrev / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID |
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改定 1.3 | 2023年11月22日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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