Entry Database : PDB / ID : 5y86 Structure visualization Downloads & linksTitle Crystal structure of kinase ComponentsDual specificity tyrosine-phosphorylation-regulated kinase 3 Details Keywords SIGNALING PROTEIN / Kinase / inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
nuclear speck organization / organelle disassembly / positive regulation of cell cycle G2/M phase transition / regulation of cellular response to stress / regulation of TORC1 signaling / dual-specificity kinase / stress granule disassembly / pericentriolar material / negative regulation of DNA damage response, signal transduction by p53 class mediator / protein serine/threonine/tyrosine kinase activity ... nuclear speck organization / organelle disassembly / positive regulation of cell cycle G2/M phase transition / regulation of cellular response to stress / regulation of TORC1 signaling / dual-specificity kinase / stress granule disassembly / pericentriolar material / negative regulation of DNA damage response, signal transduction by p53 class mediator / protein serine/threonine/tyrosine kinase activity / erythrocyte differentiation / peptidyl-threonine phosphorylation / cytoplasmic stress granule / peptidyl-serine phosphorylation / protein tyrosine kinase activity / cytoskeleton / protein kinase activity / nuclear speck / cell cycle / cell division / protein phosphorylation / intracellular membrane-bounded organelle / protein serine/threonine kinase activity / negative regulation of apoptotic process / magnesium ion binding / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol Similarity search - Function Dual specificity tyrosine-phosphorylation-regulated kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site ... Dual specificity tyrosine-phosphorylation-regulated kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Kim, K.L. / Cha, J.S. / Cho, Y.S. / Kim, H.Y. / Chang, N.P. / Cho, H.S. CitationJournal : J. Mol. Biol. / Year : 2018Title : Crystal Structure of Human Dual-Specificity Tyrosine-Regulated Kinase 3 Reveals New Structural Features and Insights into its Auto-phosphorylationAuthors : Kim, K. / Cha, J.S. / Cho, Y.S. / Kim, H. / Chang, N. / Kim, H.J. / Cho, H.S. History Deposition Aug 18, 2017 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 May 2, 2018 Provider : repository / Type : Initial releaseRevision 1.1 May 30, 2018 Group : Data collection / Database references / Category : citationItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title Revision 1.2 Nov 22, 2023 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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